Konstanty-Kalandyk Janusz, Piątek Jacek, Kędziora Anna, Miszalski-Jamka Tomasz, Kapelak Bogusław, Bartuś Krzysztof, Darocha Tomasz, Drwiła Rafał, Sadowski Jerzy
Przegl Lek. 2017;74(3):91-5.
Coronary artery disease is a major cause of death worldwide. Despite different standard revascularization options, significant number of patients remains not suitable for any treatment. The aim of the study was to evaluate long-term outcome of patients with diffuse coronary artery disease, treated with autologous stem cells injections combined with transmyocardial laser revascularization.
9 patients underwent Holmium:YAG laser revascularization and autologous bone marrow derived stem cells implantation between 2007 and 2009 in the Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Kraków and were subsequently followed up in 2015.
The mean follow-up period was 73 months. The mean CCS class significantly improved (1.4±0.5 vs 3.3±1.0; p<0.001) and cardiac related hospitalizations significantly decreased (1.1±0.8 vs 3.1±2.1; p<0.001). One death due to heart failure was observed. The mean LVEF increased from 38% to 42% (p>0.05).
Clinical status improvement was observed with low mortality rate in the long-term follow-up. No new regional wall motion abnormalities were observed, and the increase of global ejection fraction was noted.
冠状动脉疾病是全球主要的死亡原因。尽管有不同的标准血运重建方案，但仍有相当数量的患者不适合任何治疗。本研究的目的是评估采用自体干细胞注射联合心肌激光血运重建术治疗弥漫性冠状动脉疾病患者的长期疗效。
2007年至2009年期间，9例患者在克拉科夫约翰·保罗二世医院心血管外科和移植科接受了钬:钇铝石榴石激光血运重建术和自体骨髓来源干细胞植入术，并于2015年进行了随访。
平均随访期为73个月。平均加拿大心血管学会（CCS）分级显著改善（1.4±0.5对3.3±1.0；p<0.001），与心脏相关的住院次数显著减少（1.1±0.8对3.1±2.1；p<0.001）。观察到1例因心力衰竭死亡。平均左心室射血分数（LVEF）从38%增加到42%（p>0.05）。
在长期随访中观察到临床状况改善，死亡率较低。未观察到新的局部室壁运动异常，且整体射血分数有所增加。
