Transcoronary platelet activation and consumption in coronary artery disease: studies at rest.

The platelet count(PC), plasma platelet factor 4 (PF4) and plasma beta-thromboglobulin(beta TG) have been measured in blood obtained from a peripheral vein, the aortic root and the coronary sinus in 7 patients with normal coronary arteries, 9 patients with lesser degrees of coronary artery disease(CAD) and in 13 patients with severe CAD under resting conditions. In each patient group values obtained in the peripheral venous blood were similar to those obtained in normal subjects. In each group values obtained in blood from the coronary sinus were similar to those obtained in blood from the coronary aortic root and in most instances these were similar to values obtained in peripheral venous blood. for example, in the 13 subjects with hemodynamically significant 3-vessel or 2-vessel CAD the mean values in blood from a peripheral vein, the aorta and the coronary sinus respectively were: PC-194, 205, and 208 x 10(9)/1; PF4-3.3, 3.7, and 3.5 ng/ml; and beta TG-15.5, 23.0 and 18.6 ng/ml. These findings provide no support for the occurrence of continuous platelet activation or platelet consumption in the coronary vessels or elsewhere in patients with stable CAD, under resting conditions, regardless of its severity.