Kitawaki Yuko, Fujishima Fumiyoshi, Taniuchi Shinji, Saito Ryoko, Nakamura Yasuhiro, Sato Ryoko, Aoyama Yayoi, Onodera Yoshiaki, Inoshita Naoko, Matsuda Yasushi, Watanabe Mika, Sasano Hironobu
Department of Anatomic Pathology, Tohoku University Graduate School of Medicine.
Division of Pathology, Tohoku University Hospital.
Pathol Int. 2018 Jul;68(7):425-430. doi: 10.1111/pin.12677. Epub 2018 Apr 25.
Both glandular papilloma (GP) and sclerosing pneumocytoma (SP) are rare tumors in the lung. We herein report an extremely rare case of coexistence of these two uncommon tumors. The patient was a 40-year-old Japanese woman with no chief complaint. A solitary nodule of the lung was detected using chest computed tomography. The transbronchial biopsy revealed that the tumor histologically corresponded to GP. The patient subsequently underwent partial resection of the right upper lobe. Histological examination of the resected specimens further revealed that the mass contained two different and independent elements and displayed typically histological features of GP and SP. Molecular analysis further revealed the presence of BRAF V600E and AKT1 E17K mutations in GP, whereas only AKT1 mutation was detected in SP. To our knowledge, this is the first case of coexistence of GP and SP in the bronchiole harboring common AKT1 mutation and different BRAF V600E mutational status.
腺性乳头状瘤（GP）和硬化性肺细胞瘤（SP）均为肺部罕见肿瘤。我们在此报告一例这两种不常见肿瘤共存的极其罕见病例。患者为一名40岁无主诉的日本女性。通过胸部计算机断层扫描检测到肺部有一个孤立结节。经支气管活检显示，该肿瘤在组织学上符合GP。患者随后接受了右上叶部分切除术。对切除标本的组织学检查进一步显示，肿块包含两种不同且独立的成分，并呈现出典型的GP和SP组织学特征。分子分析进一步显示，GP中存在BRAF V600E和AKT1 E17K突变，而在SP中仅检测到AKT1突变。据我们所知，这是第一例在细支气管中GP和SP共存且具有共同AKT1突变和不同BRAF V600E突变状态的病例。
