Xu Juan, Zuo Yu
Reproductive Medicine Center, Lianyungang Maternity and child Health Care Hospital, Lianyungang 222006, Jiangsu Province, China.
Zhongguo Zhen Jiu. 2018 Apr 12;38(4):358-61. doi: 10.13703/j.0255-2930.2018.04.004.
To observe the efficacy differences between acupuncture combined with medication and medication alone for infertility patients with polycystic ovary syndrome (PCOS).
According to random number table, a total of 60 infertility patients with PCOS were randomly assigned into an observation group and a control group, 30 cases in each one. The patients in the control group were treated with diane-35 from the 3rd day into menstruation, and one menstrual cycle was taken as a session of treatment. At the same time of using diane-35, the patients in the observation group were treated with acupuncture at Guanyuan (CV 4), Qihai (CV 6), Sanyinjiao (SP 6), Zusanli (ST 36), Zigong (EX-CA 1), Shenshu (BL 23), Pishu (BL 20), Weishu (BL 21) and Ganshu (BL 18) during non-menstruation period; the acupuncture was given once every two days, three treatments per week. The patients in both groups were treated for two sessions. The basic sex hormone and body mass index (BMI) were compared between the two groups before and after treatment. After ovulation induction treatment, the endometrial thickness, amount of mature follicle, ovulation rate, clinical pregnancy rate, occurrence rate of ovarian hyperstimulation syndrome (OHSS) and the number of early spontaneous abortion were compared between the two groups during ovulation.
After treatment, the luteinizing hormone (LH), testosterone (T) and BMI reduced in the observation group (all <0.05), while only LH reduced in the control group (<0.05). The reducing of estradiol (E), T and BMI in the observation group was more significant than that in the control group (all <0.05). The ovulation rate was 93.3% (28/30) in the observation group, which was higher than 80.0% (24/30) in the control group (<0.05). The rate of clinical pregnancy was 43.3% (13/30) in the observation group, which was higher than 33.3% (10/30) in the control group (<0.05). The differences of endometrial thickness, amount of mature follicle, occurrence rate of OHSS and number of early spontaneous abortion were not significant between the two groups (all >0.05).
Acupuncture as adjunctive treatment could improve BMI, reduce the levels of LH, E and T, increase ovulation reaction and effectively shorten reproduction cycles in infertility patients with PCOS.
观察针刺联合药物与单纯药物治疗多囊卵巢综合征（PCOS）所致不孕症患者的疗效差异。
按照随机数字表法，将60例PCOS所致不孕症患者随机分为观察组和对照组，每组30例。对照组于月经第3天开始服用达英-35，以1个月经周期为1个疗程。观察组在服用达英-35的同时，于非经期针刺关元（CV4）、气海（CV6）、三阴交（SP6）、足三里（ST36）、子宫（EX-CA1）、肾俞（BL23）、脾俞（BL20）、胃俞（BL21）、肝俞（BL18）；针刺每2天1次，每周3次。两组患者均治疗2个疗程。比较两组治疗前后基础性激素及体重指数（BMI）。诱导排卵治疗后，比较两组排卵期子宫内膜厚度、成熟卵泡数量、排卵率、临床妊娠率、卵巢过度刺激综合征（OHSS）发生率及早期自然流产次数。
治疗后，观察组促黄体生成素（LH）、睾酮（T）及BMI降低（均P<0.05），而对照组仅LH降低（P<0.05）。观察组雌二醇（E）、T及BMI降低幅度大于对照组（均P<0.05）。观察组排卵率为93.3%（28/30），高于对照组的80.0%（24/30）（P<0.05）。观察组临床妊娠率为43.3%（13/30），高于对照组的33.3%（10/30）（P<0.05）。两组子宫内膜厚度、成熟卵泡数量、OHSS发生率及早期自然流产次数比较，差异均无统计学意义（均P>0.05）。
针刺辅助治疗可改善PCOS所致不孕症患者的BMI，降低LH、E及T水平，增加排卵反应，有效缩短生育周期。
