Dai Zeqi, Sun Weiwei, Zhao Ruihua
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Beijing University of CM, Beijing 100029.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Zhongguo Zhen Jiu. 2018 Apr 12;38(4):451-5. doi: 10.13703/j.0255-2930.2018.04.030.
The research of acupuncture and moxibustion for endometrial receptivity in recent 10 years was reviewed. CNKI and PubMed databases were retrieved with "acupuncture" "moxibustion" and "endometrial receptivity" as key words. The retrieving time was from January of 2007 through December of 2016. As a result, 63 relevant papers were collected and 28 papers regarding clinical and experimental researches of acupuncture for endometrial receptivity were included into analysis. It was found that acupuncture and moxibustion could improve endometrial morphology (including the expression of pinopodes, endometrial thickness and the rate of endometrial type A), reduce the endometrial microcirculation (including endometrial pulsatility index, resistance index and hemodynamic index), increase the levels of estrogen and progesterone and the expressions of their receptors, and regulate the expression of molecular biological regulator (such as integrin, leukemia inhibitory factor, vascular endothelial growth factor and HOXA10). As a result, the endometrial receptivity was improved to provide good environment for embryo implantation and improve the pregnancy rate, which had significant advantage in the field of assisted reproductive technology. However, detections of pinopodes and integrin were invasive. Its application for clinical use had limitations. In addition, the evidence of acupuncture improving endometrial receptivity was still insufficient. By reviewing related research result, this paper further summarized and analyzed the action mechanism of acupuncture for endometrial receptivity to provide references for the clinical treatment.
回顾近10年针灸对子宫内膜容受性的研究。以“针灸”“艾灸”和“子宫内膜容受性”为关键词检索中国知网和PubMed数据库。检索时间为2007年1月至2016年12月。结果，收集到63篇相关论文，纳入28篇关于针灸改善子宫内膜容受性的临床和实验研究论文进行分析。发现针灸可改善子宫内膜形态（包括胞饮突表达、子宫内膜厚度和A型子宫内膜率），降低子宫内膜微循环（包括子宫内膜搏动指数、阻力指数和血流动力学指数），提高雌激素和孕激素水平及其受体表达，调节分子生物学调节因子（如整合素、白血病抑制因子、血管内皮生长因子和HOXA10）的表达。结果，子宫内膜容受性得到改善，为胚胎着床提供良好环境，提高妊娠率，在辅助生殖技术领域具有显著优势。然而，胞饮突和整合素的检测具有侵入性。其临床应用存在局限性。此外，针灸改善子宫内膜容受性的证据仍不足。通过回顾相关研究结果，本文进一步总结和分析了针灸改善子宫内膜容受性的作用机制，为临床治疗提供参考。
