Department of Emergency Medicine, Jining First People's Hospital, Jining, China.
Department of Electrocardiogram, The People's Hospital of Zhangqiu Area, Jinan, China.
Minerva Med. 2019 Apr;110(2):115-120. doi: 10.23736/S0026-4806.18.05635-5. Epub 2018 Apr 24.
To investigate the detection rate and influencing factors of obstructive sleep apnea syndrome (OSAS) in middle-aged and elderly patients with hypertension.
A total of 440 patients with hypertension were selected as the research objects, all of them participated in the Berlin questionnaire survey, and the polysomnography (PSG) was performed on the patients with a high risk of OSAS. The detection rate of OSAS was analyzed, the clinical data between non-OSAS group and OSAS group were compared and stepwise linear regression and logistic regression were used to analyze the related influencing factors to Apnea Hypopnea Index (AHI) and OSAS in hypertensive patients.
A total of 235 patients completed PSG and 196 patients were diagnosed as OSAS with the detection rate of 83.40%. The detection rate of OSAS in male patients was higher than that in females (89.04% vs.74.16%, χ2=8.025, P=0.006). The detection rates of OSAS in normal BMI group, overweight group and obesity group were 56.52%, 92.37% and 100%, respectively (χ2=36.438, P<0.001). The detection rates of OSAS in normal waistline group and central obesity group were 74.42% and 88.59% (χ2=7.539, P=0.016). The detection rates of OSAS in grade 1, grade 2, and grade 3 hypertension groups were 57.47%, 98.23%, and 100%, respectively (χ2=44.623, P<0.001). BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), low density lipoprotein (LDL) and waist circumference of OSAS group were all higher than those in non-OSAS group (P<0.05). BMI, SBP and DBP were positively correlated with AHI (P<0.05), which were independent risk factors of OSAS (OR=2.548 [95% CI: 1.449-4.327], 1.342 [95% CI: 1.214-1.965] and 1.169 [95% CI: 1.025-1.622], respectively, P<0.05).
The incidence of OSAS in middle-aged and elderly patients with hypertension is high. High BMI, SBP, and DBP are independent risk factors of OSAS.
探讨中老年高血压患者阻塞性睡眠呼吸暂停综合征（OSAS）的检出率及影响因素。
选取 440 例高血压患者为研究对象，均参与柏林问卷调查，对 OSAS 高危患者行多导睡眠图（PSG）检查，分析 OSAS 的检出率，比较非 OSAS 组和 OSAS 组的临床资料，采用逐步线性回归和 logistic 回归分析与 AHI 和 OSAS 相关的影响因素。
共 235 例患者完成 PSG，其中 196 例诊断为 OSAS，检出率为 83.40%。男性患者 OSAS 检出率高于女性（89.04% vs.74.16%，χ2=8.025，P=0.006）。正常 BMI 组、超重组和肥胖组 OSAS 检出率分别为 56.52%、92.37%和 100%（χ2=36.438，P<0.001）。正常腰围组和中心性肥胖组 OSAS 检出率分别为 74.42%和 88.59%（χ2=7.539，P=0.016）。1 级、2 级和 3 级高血压组 OSAS 检出率分别为 57.47%、98.23%和 100%（χ2=44.623，P<0.001）。OSAS 组 BMI、收缩压（SBP）、舒张压（DBP）、低密度脂蛋白（LDL）和腰围均高于非 OSAS 组（P<0.05）。BMI、SBP 和 DBP 与 AHI 呈正相关（P<0.05），是 OSAS 的独立危险因素（OR=2.548[95%CI：1.449-4.327]，1.342[95%CI：1.214-1.965]和 1.169[95%CI：1.025-1.622]，P<0.05）。
中老年高血压患者 OSAS 发病率较高，高 BMI、SBP 和 DBP 是 OSAS 的独立危险因素。
