两倍的铜锌超氧化物歧化酶活性表明红毛猩猩21号染色体存在纯合亚显微重复。
Twofold CuZnSOD activity suggesting homozygous submicroscopic duplication of chromosome 21 in the orangutan.
作者信息
de Grouchy J, Nicole A, Cochet C, Créau-Goldberg N, Sinet P M
机构信息
U 173 INSERM, Hôpital Necker-Enfants Malades, Paris.
出版信息
Ann Genet. 1988;31(2):73-4.
A twofold CuZnSOD activity was observed in an orangutan as compared to man and a chimpanzee. This suggests that a submicroscopic duplication of chromosome 21 (similar to those demonstrated in patients with the trisomy 21 phenotype but with a normal karyotype) has occurred in the homozygous state during evolution of the orangutan phylum. Such duplications could be important evolutionary mechanisms, together with visible chromosome rearrangements and classical gene mutations.
与人类和黑猩猩相比，在一只猩猩中观察到了两倍的铜锌超氧化物歧化酶（CuZnSOD）活性。这表明在猩猩类进化过程中，21号染色体发生了纯合状态的亚显微重复（类似于21三体综合征表型但核型正常的患者中所显示的情况）。这种重复可能是重要的进化机制，与可见的染色体重排和经典基因突变一起发挥作用。
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