维生素 K1 和维生素 K2 对儿童特应性皮炎患者外周血单个核细胞增殖、细胞因子产生和调节性 T 细胞频率的影响。
The effects of vitamin K1 and vitamin K2 on the proliferation, cytokine production and regulatory T-cell frequency in peripheral blood mononuclear cells of paediatric atopic dermatitis patients.
机构信息
Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji City, Tokyo, Japan.
Department of Pharmacy, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
出版信息
Exp Dermatol. 2018 Sep;27(9):1058-1060. doi: 10.1111/exd.13671. Epub 2018 Aug 3.
We estimated the pharmacological efficacy of vitamin K (VK ) and VK on the mitogen-activated peripheral blood mononuclear cells (PBMCs) of paediatric atopic dermatitis (AD) patients. VK suppressed the in vitro proliferation of T-cell mitogen-activated PBMCs of AD patients. In contrast, VK had little effect on the PBMC proliferation. The IL-2 production from the activated PBMCs of AD patients significantly increased (P < .05), while the production significantly decreased by 100 μmol L VK (P < .01). In addition, 100 μmol L VK reduced the percentage of CD4+ and CD4+CD25+ cells in PBMCs. These results suggest that VK2 can modulate T-cell function in PBMCs of AD patients.
我们评估了维生素 K（VK）及其类似物对儿科特应性皮炎（AD）患者外周血单个核细胞（PBMCs）有丝分裂原激活的药理学疗效。VK 抑制 AD 患者 T 细胞丝裂原激活的 PBMC 体外增殖。相比之下，VK 对 PBMC 增殖的影响很小。AD 患者激活的 PBMC 中白细胞介素-2（IL-2）的产生显著增加（P<.05），而 100μmol/L VK 可使 IL-2 的产生显著减少（P<.01）。此外，100μmol/L VK 降低了 PBMC 中 CD4+和 CD4+CD25+细胞的比例。这些结果表明，VK2 可调节 AD 患者 PBMC 中的 T 细胞功能。
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