维生素 K2 的免疫调节作用：对骨骼健康的影响。
Immunomodulatory effect of vitamin K2: Implications for bone health.
机构信息
Adult Stem Cell Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA.
出版信息
Oral Dis. 2018 Mar;24(1-2):67-71. doi: 10.1111/odi.12759.
OBJECTIVE
In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non-vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T-cell suppression by vitamin K2.
MATERIALS AND METHODS
Peripheral blood mononuclear cells (PBMCs) from three healthy donors were used. The PBMCs were stimulated with the mitogens phytohemagglutinin and concanavalin A, and T-cell proliferation was analyzed using flow cytometry based on carboxyfluorescein succinimidyl ester (CSFE) dye dilution.
RESULTS
Vitamin K2 (60 and 100 μM) inhibited T-cell proliferation. Vitamin K1 at the same concentrations did not inhibit T-cell proliferation.
CONCLUSION
Vitamin K2 has immunomodulatory activities.
目的
在绝经后骨质疏松症女性中，维生素 K2 似乎可降低髋部、椎体和非椎体骨折的发生率。与健康绝经后和绝经前女性相比，绝经后骨质疏松症女性的循环活化 T 细胞更多，但维生素 K2 对 T 细胞的影响尚未得到研究。在这项研究中，我们研究了维生素 K2 对 T 细胞的抑制作用。
材料和方法
使用了 3 名健康供体的外周血单核细胞 (PBMC)。用植物血球凝集素和伴刀豆球蛋白 A 刺激 PBMC，并使用基于羧基荧光素琥珀酰亚胺酯 (CSFE) 染料稀释的流式细胞术分析 T 细胞增殖。
结果
维生素 K2（60 和 100μM）抑制 T 细胞增殖。相同浓度的维生素 K1 则不抑制 T 细胞增殖。
结论
维生素 K2 具有免疫调节活性。
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