Bouchard P, Garcia E
Service d'Endocrinologie et des Maladies de la Reproduction, Hôpital de Bicêtre, Le Kremlin, France.
Horm Res. 1987;28(2-4):175-80. doi: 10.1159/000180942.
To investigate the effect of LHRH (GnRH) agonists on sperm suppression, we studied the effect of a depot preparation of D-Trp6 LHRH in 10 normal men for 30 weeks. In addition, to determine the role of androgenic substitution on sperm suppression, the volunteers were divided into two groups: group 1 (n = 5) received a low dose T substitution (125 mg of T enanthate every month), while group 2 (n = 5) received a normal T substitution (120 mg of T undecanoate every day). Four men became azoospermic in group 1 and none in group 2. Moreover, administration of additional T injections in 1 volunteer of group 1 resulted in the reappearance of spermatozoa in the ejaculate. Return to the low dose therapy produced azoospermia. These results suggest that testosterone supplementation supports spermatogenesis.
为研究促黄体生成素释放激素（LHRH，即GnRH）激动剂对精子抑制的作用，我们对10名正常男性使用长效D-色氨酸6-LHRH制剂进行了为期30周的研究。此外，为确定雄激素替代在精子抑制中的作用，志愿者被分为两组：第1组（n = 5）接受低剂量睾酮替代治疗（每月125mg庚酸睾酮），而第2组（n = 5）接受正常剂量睾酮替代治疗（每天120mg十一酸睾酮）。第1组中有4名男性出现无精子症，第2组中无人出现。此外，第1组的1名志愿者额外注射睾酮后，射精中再次出现精子。恢复低剂量治疗则导致无精子症。这些结果表明，补充睾酮可支持精子发生。
