Kodali Venkata
Sir Charles Gairdner Hospital and University of Western Australia, 51-85 Shenton Street, Geraldton, WA 6530, Australia
Rural Remote Health. 2018 Apr;18(2):4350. doi: 10.22605/RRH4350. Epub 2018 Apr 27.
Selenium is an essential micronutrient for human beings. Selenoproteins play a role in anti-oxidation and in maintaining immunity. Selenoproteins are distributed in all tissues, the most important of which are glutathione peroxidase, thioredoxin reductase and deiodinases. The deiodinases are selenium-dependent enzymes.
An elderly man with lethargy and tiredness who had normal free thyroid hormone T4, thyroid-stimulating hormone and a low T3 with subnormal temperature and low selenium level. Selenium supplementation normalised thyroid function tests.
Physicians should have high level of suspicion to identify selenium deficiency as an effective replacement will cure the causative disorder.
硒是人类必需的微量营养素。硒蛋白在抗氧化和维持免疫方面发挥作用。硒蛋白分布于所有组织中，其中最重要的是谷胱甘肽过氧化物酶、硫氧还蛋白还原酶和脱碘酶。脱碘酶是依赖硒的酶。
一名老年男性，有嗜睡和疲倦症状，其游离甲状腺激素T4、促甲状腺激素正常，但T3水平低，体温低于正常范围且硒水平低。补充硒后甲状腺功能检查恢复正常。
医生应高度怀疑以识别硒缺乏，因为有效的补充将治愈相关疾病。
