Zhang Meixing, Xu Wangjie, He Guang, Zhang Dong, Zhao Xianglong, Dai Jingbo, Wu Jiajie, Cao Yong, Wang Zhaoxia, Wang Lianyun, Qiao Zhongdong
School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240, China.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Behav Brain Res. 2018 Aug 1;348:263-266. doi: 10.1016/j.bbr.2018.04.033. Epub 2018 Apr 23.
Our previous studies showed that paternal nicotine exposure can lead to hyperactivity in the offspring. Nevertheless, the cross-generational effects of maternal and biparental nicotine exposure remain unclear. In this study, female and male mice were exposed respectively by nicotine before pregnancy. The maternal pre-pregnancy nicotine exposure led to depression-like behaviors in the F1 offspring. However, after biparental pre-pregnancy nicotine exposure, seventy percentage of the offspring exhibited a depressive phenotype while 20% were hyperactive, and the remaining exhibited no obvious abnormal behavior. The cross-generational effects appeared to be mediated via disruption of the balance between GSK3 and p-GKS3 by nicotine. These results suggested that pre-pregnancy nicotine exposure can induce alterations in the behavior of the offspring, and the cross-generational effects of maternal nicotine exposure were particularly serious.
我们之前的研究表明，父系尼古丁暴露会导致子代多动。然而，母系和双亲尼古丁暴露的跨代效应仍不清楚。在本研究中，雌雄小鼠在怀孕前分别接受尼古丁暴露。母系孕前尼古丁暴露导致F1子代出现抑郁样行为。然而，双亲孕前尼古丁暴露后，70%的子代表现出抑郁表型，20%表现为多动，其余则未表现出明显异常行为。跨代效应似乎是由尼古丁破坏GSK3和p-GKS3之间的平衡介导的。这些结果表明，孕前尼古丁暴露可诱导子代行为改变，且母系尼古丁暴露的跨代效应尤为严重。
