腺样体切除术对特应性儿童咳嗽反射敏感性的影响。
The effect of adenoidectomy on cough reflex sensitivity in atopic children.
作者信息
Sojak J, Durdik P, Zatko T, Mohamedova E O, Grendar M, Ferenc P, Kantarova D, Pecova R
机构信息
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), Department of Pathological Physiology JFM CU and Biomedical Center Martin JFM CU, Slovak Republic; Slovak Medical University in Bratislava, Faculty of Medicine, The Clinic of Otorhinolaryngology and Head and Neck Surgery, Central Military Hospital, Ruzomberok, Slovak Republic.
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, The Clinic of Children and Adolescents, University Hospital, Martin, Slovak Republic.
出版信息
Respir Physiol Neurobiol. 2018 Nov;257:115-121. doi: 10.1016/j.resp.2018.04.009. Epub 2018 Apr 23.
The aim of this study was to determine whether cough sensitivity is changed after adenoidectomy in atopic children with chronic cough. 21 Children having symptoms of chronic cough and adenoid hypertrophy verified by nasal fiberoptic endoscopy were submitted to cough sensitivity measurement before and after adenoidectomy. Their pulmonary function was within normal range. Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Children' (14 boys and 7 girls, mean age 6,52 yrs) cough sensitivity (geometric mean, with 95% CI) for C2 was preoperatively (before adenoidectomy) 19.95 (9.95-39.98) micromol/l vs. children' C2 postoperatively 14.04 (7.16-27.55) (P = .083 for Wilcoxon paired two sample test). Children' C5 was preoperatively 86.26 (39.25-189.57) micromol/l vs. C5 postoperatively 95.23 (46.33-195.75) micromol/l (P = .794 for Wilcoxon paired two sample test). We conclude that cough sensitivity for C2 and C5 was not significantly changed after adenoidectomy in atopic children with chronic cough.
本研究的目的是确定在患有慢性咳嗽的特应性儿童中，腺样体切除术后咳嗽敏感性是否发生变化。21名经鼻纤维内镜检查证实有慢性咳嗽症状和腺样体肥大的儿童在腺样体切除术前和术后接受了咳嗽敏感性测量。他们的肺功能在正常范围内。报告了引起两次咳嗽（C2）和五次咳嗽（C5）的辣椒素浓度。儿童（14名男孩和7名女孩，平均年龄6.52岁）的C2咳嗽敏感性（几何平均数，95%可信区间）术前（腺样体切除术前）为19.95（9.95 - 39.98）μmol/l，术后为14.04（7.16 - 27.55）（Wilcoxon配对双样本检验P = 0.083）。儿童的C5术前为86.26（39.25 - 189.57）μmol/l，术后为95.23（46.33 - 195.75）μmol/l（Wilcoxon配对双样本检验P = 0.794）。我们得出结论，在患有慢性咳嗽的特应性儿童中，腺样体切除术后C2和C5的咳嗽敏感性没有显著变化。
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