NNF, Departament de Psicología Bàsica, Clínica i Psicobiología, University Jaume I, Castellón, Spain.
NNF, Departament de Psicología Bàsica, Clínica i Psicobiología, University Jaume I, Castellón, Spain.
Neuropsychologia. 2018 Jun;114:88-100. doi: 10.1016/j.neuropsychologia.2018.04.020. Epub 2018 Apr 23.
According to a large neuropsychological and neuroimaging literature, the bilateral anterior temporal lobe (ATL) is a core region for semantic processing. It seems therefore surprising that semantic memory appears to be preserved in temporal lobe epilepsy (TLE) patients with unilateral ATL resection. However, recent work suggests that the bilateral semantic system is relatively robust against unilateral damage and semantic impairments under these circumstances only become apparent with low frequency specific concepts. In addition, neuroimaging studies have shown that the function of the left and right ATLs differ and therefore left or right ATL resection should lead to a different pattern of impairment. The current study investigated hemispheric differences in the bilateral semantic system by comparing left and right resected TLE patients during verbal semantic processing of low frequency concepts. Picture naming and semantic comprehension tasks with varying word frequencies were included to investigate the pattern of impairment. Left but not right TLE patients showed impaired semantic processing, which was particularly apparent on low frequency items. This indicates that, for verbal information, the bilateral semantic system is more sensitive to damage in the left compared to the right ATL, which is in line with theories that attribute a more prominent role to the left ATL due to connections with pre-semantic verbal regions.
根据大量神经心理学和神经影像学文献，双侧前颞叶（ATL）是语义处理的核心区域。因此，单侧 ATL 切除的颞叶癫痫（TLE）患者的语义记忆似乎得以保留，这似乎令人惊讶。然而，最近的研究表明，双侧语义系统相对较强韧，能够抵抗单侧损伤，只有在低频特定概念的情况下，语义障碍才会变得明显。此外，神经影像学研究表明，左、右 ATL 的功能不同，因此左或右 ATL 切除应导致不同的损伤模式。本研究通过比较左、右 TLE 患者在低频概念的言语语义处理过程中，研究了双侧语义系统的半球差异。纳入图片命名和语义理解任务，以不同的词频进行测试，以研究损伤模式。只有左 TLE 患者表现出语义处理受损，在低频项目上尤其明显。这表明，对于言语信息，双侧语义系统对左 ATL 损伤比右 ATL 更敏感，这与将左 ATL 归因于与前语义言语区域的连接而具有更突出作用的理论一致。
