Department of Gastroenterology, Faculty of Medicine, Oita, Japan.
Department of Gastroenterology, Yuri Kumiai General Hospital, Akita, Japan.
Digestion. 2018;98(2):75-80. doi: 10.1159/000487184. Epub 2018 Apr 26.
BACKGROUND/AIMS: Serologic tests are commonly used for screening Helicobacter pylori infection because they not only provide quick results but also are inexpensive. A new latex agglutination serum antibody assay (LZ test) has been developed and it is expected to be as effective as conventional assays. This study aimed to calculate a reliable cutoff value for the LZ test and to estimate the sensitivity and specificity of the cutoff value in screening adolescents for H. pylori infection in Japan.
We screened junior high school students in Akita Prefecture, Japan, for H. pylori infection. We used the data of 213 such students who underwent H. pylori stool antigen (HpSA) tests in 2016. The students who had positive results with HpSA tests were diagnosed with H. pylori infection. Of the 213 students, 209 underwent the LZ test.
The prevalence rate of H. pylori infection was 3.8% (8/209). The area under the curve for the LZ test was 0.88. The cutoff value of the LZ test was determined to be 3.1 U/mL. At this value, the sensitivity and specificity were 87.5 and 91.5%, respectively.
The accuracy of the LZ test in adolescents was well balanced for sensitivity and specificity as well as for tolerable results.
背景/目的：血清学检测常用于筛查幽门螺杆菌感染，因为它们不仅结果快速，而且价格低廉。一种新的乳胶凝集血清抗体检测（LZ 检测）已经开发出来，预计其效果与常规检测相当。本研究旨在计算 LZ 检测的可靠截断值，并评估该截断值在日本青少年中筛查幽门螺杆菌感染的敏感性和特异性。
我们在日本秋田县筛查了初中生的幽门螺杆菌感染情况。我们使用了 2016 年接受幽门螺杆菌粪便抗原（HpSA）检测的 213 名学生的数据。HpSA 检测阳性的学生被诊断为幽门螺杆菌感染。在这 213 名学生中，有 209 名学生接受了 LZ 检测。
幽门螺杆菌感染的患病率为 3.8%（8/209）。LZ 检测的曲线下面积为 0.88。LZ 检测的截断值确定为 3.1 U/mL。在此值下，灵敏度和特异性分别为 87.5%和 91.5%。
LZ 检测在青少年中的准确性在灵敏度和特异性以及可接受的结果方面具有良好的平衡。
