Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.
The Gastroenterology Center, The First Central Hospital of Mongolia, Ulaanbaatar, Mongolia.
Gut Liver. 2024 Jan 15;18(1):60-69. doi: 10.5009/gnl220464. Epub 2023 Sep 18.
BACKGROUND/AIMS: : A latex agglutination turbidity (LA) assay to test for serum antibodies has been approved in Japan and Korea for mass screening of infection. In this study, we evaluated the LA assay for diagnosing infection and predicting gastric mucosal changes in a Mongolian population.
: In total, 484 individuals were classified into -positive (n=356) and -negative (n=128) groups, as determined by histology and culture.
: The best cutoff, sensitivity, and specificity values for the LA assay were 18.35 U/mL, 74.2%, and 65.6%, respectively. The LA values in the atrophic gastritis group were statistically higher than those in the other groups (healthy, chronic gastritis, intestinal metaplasia, and gastric cancer, p<0.0001). The cutoff value to distinguish the atrophic gastritis group from the other four groups was 32.0 U/mL, and its area under the curve was 0.673, which was the highest among the E-plate, pepsinogen (PG) I, PG II, and PG I/II ratio tests in our data. The odds ratios for atrophic gastritis determined by the LA assay and PG I test in multiple logistic regression were 2.5 and 1.9, respectively, which were significantly higher than for the other tests.
: The LA assay can determine the risk of atrophic gastritis, which in turn is a considerable risk factor for gastric cancer. We propose using this assay in combination with the PG I/II ratio to avoid missing gastric cancer patients who have a low LA value (less than 32.0 U/mL).
背景/目的：一种乳胶凝集浊度（LA）检测法已在日本和韩国获得批准，用于 感染的大规模筛查。本研究旨在评估该 LA 检测法在蒙古人群中诊断 感染和预测胃黏膜变化的能力。
共 484 例个体根据组织学和培养结果分为阳性（n=356）和阴性（n=128）组。
LA 检测法的最佳截断值、灵敏度和特异性分别为 18.35 U/mL、74.2%和 65.6%。萎缩性胃炎组的 LA 值明显高于其他组（健康组、慢性胃炎组、肠上皮化生组和胃癌组，p<0.0001）。区分萎缩性胃炎组和其他四组的截断值为 32.0 U/mL，其曲线下面积为 0.673，在 E 板、胃蛋白酶原（PG）I、PG II 和 PG I/II 比值检测中最高。LA 检测法和 PG I 检测法在多因素逻辑回归中预测萎缩性胃炎的比值比分别为 2.5 和 1.9，均显著高于其他检测法。
LA 检测法可确定发生萎缩性胃炎的风险，而萎缩性胃炎又是胃癌的一个重要危险因素。我们建议将该检测法与 PG I/II 比值联合使用，以避免漏诊 LA 值较低（<32.0 U/mL）的胃癌患者。
