血清万古霉素谷浓度在治疗凝固酶阴性葡萄球菌引起的中枢神经系统分流感染中的作用

Impact of Serum Vancomycin Trough Levels in the Treatment of Central Nervous System Shunt Infections Caused by Coagulase-Negative Staphylococci.

作者信息

Gibson Ashley, Kaplan Sheldon L, Vallejo Jesus G

机构信息

Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.

Section of Infectious Diseases, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.

出版信息

Pediatr Neurosurg. 2018;53(4):243-246. doi: 10.1159/000488498. Epub 2018 Apr 26.

DOI:10.1159/000488498

PMID:29698961

Abstract

Coagulase-negative staphylococci (CoNS) are a common cause of pediatric ventricular shunt infections. The Infectious Diseases Society of America recommends vancomycin serum troughs of 15-20 µg/mL when treating CoNS shunt infections in adult patients. We report a series of pediatric cases of CoNS shunt infections in which clinical cure was obtained with troughs < 15 µg/mL. These findings question the relevance of this recommendation in pediatric patients.

摘要

凝固酶阴性葡萄球菌（CoNS）是儿童脑室分流感染的常见原因。美国传染病学会建议，在治疗成年患者的CoNS分流感染时，万古霉素血清谷浓度应为15 - 20µg/mL。我们报告了一系列CoNS分流感染的儿科病例，这些病例在谷浓度低于15µg/mL时获得了临床治愈。这些发现对该建议在儿科患者中的相关性提出了质疑。