Diaz-Mitoma F, Harding G K, Hoban D J, Roberts R S, Low D E
J Infect Dis. 1987 Oct;156(4):555-60. doi: 10.1093/infdis/156.4.555.
Coagulase-negative staphylococci (CNST) are the most-common cause of ventriculoperitoneal shunt infections. Some of these strains produce a slime-like substance. We reviewed 19 episodes of ventriculoperitoneal shunt infections due to CNST in 17 patients. Eleven episodes of infection were caused by slime-producing CNST and eight by non-slime-producing CNST. Shunt obstruction and abdominal pain occurred more frequently when infectious episodes were due to slime-producing CNST than to non-slime-producing CNST (P less than .05). Despite appropriate antimicrobial therapy, the mean duration of fever was longer and the failure to eradicate the infecting organisms was more frequent when the infectious episodes were due to slime-producing CNST than to non-slime-producing CNST (P less than .025). Discriminate function analysis found, however, that only failure to eradicate the infecting organism (by antimicrobial therapy) occurred more frequently in infectious episodes due to slime-producing CNST than to non-slime-producing CNST (P = .01).
凝固酶阴性葡萄球菌（CNST）是脑室腹腔分流感染最常见的病因。其中一些菌株会产生一种黏液样物质。我们回顾了17例患者中因CNST导致的19次脑室腹腔分流感染事件。11次感染由产黏液CNST引起，8次由不产黏液CNST引起。与不产黏液CNST引起的感染发作相比，产黏液CNST引起感染发作时，分流梗阻和腹痛更为常见（P<0.05）。尽管进行了适当的抗菌治疗，但与不产黏液CNST引起的感染发作相比，产黏液CNST引起感染发作时，平均发热持续时间更长，且未能根除感染病原体的情况更频繁（P<0.025）。然而，判别功能分析发现，只有（通过抗菌治疗）未能根除感染病原体在产黏液CNST引起的感染发作中比在不产黏液CNST引起的感染发作中更频繁发生（P = 0.01）。
