Radtke Arlo, Hennig Finja, Ikogho Raphael, Hammel Johannes, Anheuser Petra, Wülfing Christian, Belge Gazanfer, Dieckmann Klaus-Peter
Faculty of Biology and Chemistry, University of Bremen, Bremen, Germany.
Department of Urology, Albertinen Krankenhaus, Hamburg, Germany.
Urol Int. 2018;100(4):470-475. doi: 10.1159/000488771. Epub 2018 Apr 26.
Accumulating evidence suggests serum levels of microRNA (miR)-371a-3p to be a novel tumour marker of testicular germ cell tumours (GCTs). Presently, there is only limited information regarding the velocity of decline of serum levels in response to treatment.
Twenty-four patients with testicular GCT (20 seminoma, 4 nonseminoma, median age 40 years) with clinical stage 1 had measurements of serum levels of miR-371a-3p preoperatively and repeatedly on the following 3 days. Three had additional tests done within 24 h after surgery. Measurement results were analysed using descriptive statistical methods.
Serum levels dropped to 2.62, 1.27, and 0.47% of the preoperative level within 1, 2, and 3 days, respectively. The computed half-life amounts to 3.7-7 h. The velocity of decay is significantly associated with tumour size.
Serum-levels of miR-371a-3p have a short half-life of less than 12 h. The rapid decay after treatment represents a valuable feature confirming the usefulness of miR-371a-3p as a valuable serum biomarker of GCT.
越来越多的证据表明，血清微小RNA（miR）-371a-3p水平是睾丸生殖细胞肿瘤（GCT）的一种新型肿瘤标志物。目前，关于血清水平对治疗反应的下降速度的信息有限。
24例临床分期为1期的睾丸GCT患者（20例精原细胞瘤，4例非精原细胞瘤，中位年龄40岁）在术前及术后3天内多次测量血清miR-371a-3p水平。3例患者在术后24小时内进行了额外检测。采用描述性统计方法分析测量结果。
血清水平在1天、2天和3天内分别降至术前水平的2.62%、1.27%和0.47%。计算得出的半衰期为3.7 - 7小时。衰减速度与肿瘤大小显著相关。
miR-371a-3p的血清水平半衰期短，小于12小时。治疗后迅速衰减是一个有价值的特征，证实了miR-371a-3p作为GCT有价值血清生物标志物的有用性。
