单侧卵巢切除大鼠的卵泡发育
Ovarian follicular development in the unilateral ovariectomized rat.
作者信息
Kagabu Satosi, Umezu Motoaki
机构信息
Faculty of Agriculture, Yamaguchi University, Yamaguchi, and.
Faculty of Agriculture, Utsunomiya University, Utsunomiya, Japan.
出版信息
Reprod Med Biol. 2005 Mar 7;4(1):89-92. doi: 10.1007/BF03016142. eCollection 2005 Mar.
Following unilateral ovariectomy, the contralateral ovary underwent hypertrophy and the number of ovulations remained unchanged. The aim of the present study was to elucidate the mechanism, which occurred by this compensation, through examination of ovarian follicular development in operated rats. Rats were examined 1-8 weeks post unilateral operation. The ovaries were serially sectioned. All sections were examined and the size of each follicle was measured. Large follicles soon recovered after surgery, but it took 5 weeks for small and medium-sized follicles to recover. The rate of atresia at the 'critical point' was 31.1% in unilateral ovariectomized animals and 73.9% in the sham-operated rats. These findings showed that in operated rats, the recovery of the number of follicles varied depending on the size of the follicle. Compared with the control animals, approximately twice as many large healthy follicles were saved from atresia at the 'critical point', producing a compensatory increase in the ovulation number ( 0.01). (Reprod Med Biol 2005; : 89-93).
单侧卵巢切除术后，对侧卵巢发生肥大，排卵数量保持不变。本研究的目的是通过检查手术大鼠的卵巢卵泡发育情况，阐明这种代偿发生的机制。在单侧手术后1至8周对大鼠进行检查。将卵巢连续切片。检查所有切片并测量每个卵泡的大小。大卵泡在手术后很快恢复，但中小卵泡需要5周才能恢复。单侧卵巢切除动物在“临界点”的闭锁率为31.1%，假手术大鼠为73.9%。这些发现表明，在手术大鼠中，卵泡数量的恢复因卵泡大小而异。与对照动物相比，在“临界点”时，大约有两倍数量的健康大卵泡从闭锁中被挽救下来，导致排卵数量代偿性增加（P<0.01）。（《生殖医学与生物学》2005年；：89 - 93）
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