Toshimori Kiyotata, Maekawa Mamiko, Ito Chizuru, Toyama Yoshiro, Suzuki-Toyota Fumie, Saxena Dinesh K
Department of Anatomy and Developmental Biology, Chiba University Graduate School of Medicine, Chiba, Japan and.
Reproductive Immunology Laboratory of National Institute for Research on Reproductive Health (ICMR), Parel, Mumbai, India.
Reprod Med Biol. 2006 May 19;5(2):87-93. doi: 10.1007/BF03016144. eCollection 2006 Jun.
The immunoglobulin superfamily (IgSF) proteins are expressed on the plasma membrane between Sertoli cells and germ cells in the testis. IgSF proteins are specifically present at the apical Sertoli-germ cell junction, that is, ectoplasmic specialization and are involved in germ cell differentiation. Some IgSF proteins are present on the surface of germ cells and undergo further biochemical modifications during sperm maturation. These IgSF proteins undergo final modifications during capacitation and/or the acrosome reaction. The function and expression of IgSF proteins in the testis and spermatozoa, as they relate to spermatogenesis and sperm-egg interaction, are discussed. (Reprod Med Biol 2006; : 87-93).
免疫球蛋白超家族（IgSF）蛋白在睾丸支持细胞和生殖细胞之间的质膜上表达。IgSF蛋白特异性地存在于支持细胞-生殖细胞顶端连接部位，即外质特化部位，并参与生殖细胞分化。一些IgSF蛋白存在于生殖细胞表面，并在精子成熟过程中经历进一步的生化修饰。这些IgSF蛋白在获能和/或顶体反应过程中经历最终修饰。本文讨论了IgSF蛋白在睾丸和精子中的功能及表达，及其与精子发生和精卵相互作用的关系。（《生殖医学与生物学》2006年；：87 - 93）
