Garcia Patricia C, Rubio Eliana M, Pereira Oduvaldo C M
Department of Pharmacology, Institute of Bioscience and.
Department of Urology, Faculty of Medicine, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.
Reprod Med Biol. 2007 Feb 16;6(1):33-38. doi: 10.1111/j.1447-0578.2007.00162.x. eCollection 2007 Mar.
Antisperm antibodies (ASA) in males cause the autoimmune disease 'immune infertility'. The present study intended to detect the presence of ASA and their incidence in men with unexplained infertility, as well as to evaluate the correlation between the presence of ASA and semen parameter alterations. Blood and sperm assessment were collected to carry out a direct and indirect mixed antiglobulin reaction (MAR) test and semen analysis in infertile and fertile men from the University Hospital of the Faculty of Medicine, Sao Paulo State University, Sao Paulo. In the MAR test, 18.18% of infertile men were positive for ASA. In fertile men, no positivity was found. A significant correlation between the presence of ASA with an increased white blood cell count plus a decreased hypoosmotic swelling test result was observed. The results indicate that ASA are involved in reduced fertility. It is not ASA detection that provides conclusive information about the occurrence of damage to fertility. The correlation between infertility and altered seminal parameters reinforce the ASA participation in this pathology. (Reprod Med Biol 2007; : 33-38).
男性体内的抗精子抗体（ASA）会引发自身免疫性疾病“免疫性不育症”。本研究旨在检测不明原因不育男性体内ASA的存在情况及其发生率，并评估ASA的存在与精液参数改变之间的相关性。圣保罗州立大学医学院大学医院收集了不育和可育男性的血液及精子样本，进行直接和间接混合抗球蛋白反应（MAR）试验以及精液分析。在MAR试验中，18.18%的不育男性ASA呈阳性。在可育男性中，未发现阳性结果。观察到ASA的存在与白细胞计数增加以及低渗肿胀试验结果降低之间存在显著相关性。结果表明，ASA与生育力降低有关。并非ASA检测就能提供关于生育力受损发生的确切信息。不育与精液参数改变之间的相关性进一步证明了ASA参与了这一病理过程。（《生殖医学与生物学》2007年；：33 - 38）
