Terada Misao, Matsumura Atsufumi, Kromkhun Pudcharaporn, Taniguchi Kazumi, Sato Fumio, Sakurai Fujiro, Yokosuka Makoto, Nagy Gyorgy M, Saito Toru R
Division of Laboratory Animal Science Nippon Medical School Bunkyo-ku Tokyo Japan.
Behavioral Neuroscience Laboratory, Graduate School of Veterinary Medicine Nippon Veterinary and Life Science University 1-7-1 Kyonan-cho 180-8602 Musashino Tokyo Japan.
Reprod Med Biol. 2009 Mar 17;8(2):59-62. doi: 10.1007/s12522-009-0009-x. eCollection 2009 Jun.
Sudden cardiac death after ejaculation has been reported in humans and highlights the important relationship between sexual behavior and the heart. The rat is an extremely useful animal model for investigating reproductive function in male mammals. In this study, we examined the relationship between autonomic nervous system activity and the circulatory system during sexual behavior in male rats.
Male Wistar-Imamichi rats were exposed to female rats in estrous and heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and plasma noradrenaline (NA) and adrenaline (Ad) concentrations were measured by telemetry during copulation.
The resting HR was 365.5 ± 18.4 beats/min (mean ± SE), which increased to 531.2 ± 21.1 beats/min at ejaculation and decreased to 404.6 ± 30.7 beats/min 1 min after ejaculation. At rest, SBP and DBP were 123.8 ± 6.6 and 81.5 ± 4.1 mmHg, respectively, which increased to 154.5 ± 5.9 and 112.1 ± 7.3 mmHg at ejaculation. Baseline plasma Ad and NA concentrations were 151.6 ± 32.0 and 248.5 ± 22.5 pg/ml, respectively, and these increased to 393.8 ± 89.9 and 792.7 ± 154.0 pg/ml at ejaculation, after which they decreased to resting levels. The rate of increase in NA at ejaculation differed significantly from that of Ad.
The load on the circulatory and autonomic nervous systems is controlled by a rapid decrease in HR and NA concentration immediately after ejaculation, such that the male rat is prepared for the next copulation.
人类射精后发生心源性猝死的情况已有报道，这凸显了性行为与心脏之间的重要关系。大鼠是研究雄性哺乳动物生殖功能极为有用的动物模型。在本研究中，我们研究了雄性大鼠性行为期间自主神经系统活动与循环系统之间的关系。
将雄性Wistar-Imamichi大鼠与处于发情期的雌性大鼠放在一起，在交配过程中通过遥测技术测量心率（HR）、收缩压（SBP）、舒张压（DBP）以及血浆去甲肾上腺素（NA）和肾上腺素（Ad）的浓度。
静息心率为365.5±18.4次/分钟（平均值±标准误），射精时增至531.2±21.1次/分钟，射精后1分钟降至404.6±30.7次/分钟。静息时，SBP和DBP分别为123.8±6.6和81.5±4.1 mmHg，射精时分别增至154.5±5.9和112.1±7.3 mmHg。血浆Ad和NA的基线浓度分别为151.6±32.0和248.5±22.5 pg/ml，射精时分别增至393.8±89.9和792.7±154.0 pg/ml，之后降至静息水平。射精时NA的增加速率与Ad的增加速率有显著差异。
射精后心率和NA浓度迅速下降，从而控制循环系统和自主神经系统的负荷，使雄性大鼠为下一次交配做好准备。
