天然沙尘对小鼠雄性生殖功能的加重作用。
Aggravating effect of natural sand dust on male reproductive function in mice.
作者信息
Yoshida Seiichi, Hiyoshi Kyoko, Ichinose Takamichi, Nishikawa Masataka, Takano Hirohisa, Sugawara Isamu, Takeda Ken
机构信息
Department of Health Sciences Oita University of Nursing and Health Sciences 2944-9 Megusuno 870-1201 Oita Oita Japan.
Environmental Chemistry Division National Institute for Environmental Studies 16-2 Onogawa 305-0053 Tsukuba Ibaraki Japan.
出版信息
Reprod Med Biol. 2009 Jul 31;8(4):151-156. doi: 10.1007/s12522-009-0027-8. eCollection 2009 Dec.
PURPOSE
Although adverse health effects of environment (such as cadmium, pesticides, diesel exhaust, etc.) on the male reproductive system have been suggested, there is little experimental evidence of such an effect of atmospheric sand dust. In the present study, the effects of sand dust (mineral particles) were investigated on the male reproductive system of mice.
METHODS
Two types of sand dusts (Asian sand dust and Arizona sand dust) were intratracheally administered (0.1 mg/mouse 4 times every other week) to ICR male mice and then male reproductive organ weight, daily sperm production (DSP), histological analysis and serum testosterone level were measured.
RESULTS
Histological examination showed that interstitial edema was produced by both sand dust types, and partial vacuolation of the seminiferous tubules was detected in the exposed mice. Moreover, exposure to these natural sand dusts significantly decreased DSP. On the other hand, there was no significant differences in serum testosterone concentration.
CONCLUSIONS
These results suggest that natural sand dust-exposure produced adverse effects on mouse male reproductive function.
目的
尽管有研究表明环境因素（如镉、农药、柴油废气等）对男性生殖系统有不良健康影响，但关于大气沙尘对男性生殖系统产生这种影响的实验证据很少。在本研究中，我们调查了沙尘（矿物颗粒）对小鼠雄性生殖系统的影响。
方法
将两种沙尘（亚洲沙尘和亚利桑那沙尘）经气管内给予（每只小鼠0.1毫克，每隔一周给药4次）ICR雄性小鼠，然后测量雄性生殖器官重量、每日精子生成量（DSP）、进行组织学分析并检测血清睾酮水平。
结果
组织学检查表明，两种沙尘均导致间质水肿，在暴露的小鼠中检测到生精小管部分空泡化。此外，暴露于这些天然沙尘会显著降低DSP。另一方面，血清睾酮浓度没有显著差异。
结论
这些结果表明，暴露于天然沙尘会对小鼠雄性生殖功能产生不良影响。
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