肝活检中血清抵抗素水平及其受体基因表达作为非酒精性脂肪性肝病严重程度的预测指标
Serum Resistin Level and Its Receptor Gene Expression in Liver Biopsy as Predictors for the Severity of Nonalcoholic Fatty Liver Disease.
作者信息
Hegazy Mona, Abo-Elfadl Soheir, Mostafa Abeer, Ibrahim Magdy, Rashed Laila, Salman Ahmed
机构信息
Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.
Department of Pathology, National Cancer Institute, Cairo, Giza, Egypt.
出版信息
Euroasian J Hepatogastroenterol. 2014 Jul-Dec;4(2):59-62. doi: 10.5005/jp-journals-10018-1102i. Epub 2014 Jul 28.
BACKGROUND
Liver histology remains the gold standard for assessing nonalcoholic fatty liver disease (NAFLD). Noninvasive serological markers have been developed to evaluate steatosis to avoid biopsy. In NAFLD patients, serum resistin was higher than those in control lean and obese patients.
OBJECTIVE OF THE STUDY
To investigate serum resistin and its receptor gene expression in liver biopsy as predictors for NAFLD severity.
PATIENTS AND METHODS
This study was conducted on 54 obese patients, with suspected fatty liver by ultrasound (excluding diabetic, alcoholic, hepatitis C virus antibody (HCVAb) or hepatitis B surface antigen (HBsAg) positive patients). They were subjected to anthropometric measurements, laboratory studies including serum resistin, abdominal ultrasonography (US) and liver biopsy. The 15 lean subjects were included as a control group. According to biopsy results, patients were subdivided into nonalcoholic steatohepatitis (NASH) group (46 patients) and non-NASH group (8 patients).
RESULTS
Significantly higher levels of resistin were detected in NAFLD patients compared to control subjects (p = 0.0001). Also, higher levels of resistin were recorded in NASH group compared to the non-NASH group; however, the difference was not statistically significant (p = 0.584). Serum alanine aspirate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (GGT) were higher in NASH patients than non-NASH group (p = 0.223, p = 0.005 and p = 0.006 respectively). Abdominal US showed high sensitivity in NAFLD diagnosis (sensitivity of sonar in detecting steatosis grade compared to biopsy was 61% in grade 1, 25% in grade 2 and 75% in grade 3).
CONCLUSION
Serum resistin can be combined with other noninvasive markers to predict the presence of NASH as an alternative to liver biopsy. Hegazy M, Abo-Elfadl S, Mostafa A, Ibrahim M, Rashed L, Salman A. Serum Resistin Level and Its Receptor Gene Expression in Liver Biopsy as Predictors for the Severity of Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2014;4(2):59-62.
背景
肝脏组织学检查仍是评估非酒精性脂肪性肝病（NAFLD）的金标准。已开发出非侵入性血清学标志物来评估脂肪变性，以避免进行活检。在NAFLD患者中，血清抵抗素水平高于健康对照者和肥胖对照者。
研究目的
研究肝脏活检中血清抵抗素及其受体基因表达，作为NAFLD严重程度的预测指标。
患者与方法
本研究纳入54例肥胖患者，这些患者经超声检查怀疑患有脂肪肝（排除糖尿病、酒精性肝病、丙型肝炎病毒抗体（HCVAb）或乙型肝炎表面抗原（HBsAg）阳性患者）。对他们进行人体测量、实验室检查，包括血清抵抗素检测、腹部超声（US）检查和肝脏活检。纳入15例瘦人作为对照组。根据活检结果，将患者分为非酒精性脂肪性肝炎（NASH）组（46例患者）和非NASH组（8例患者）。
结果
与对照组相比，NAFLD患者血清抵抗素水平显著升高（p = 0.0001）。此外，NASH组抵抗素水平高于非NASH组；然而，差异无统计学意义（p = 0.584）。NASH患者血清丙氨酸天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和γ-谷氨酰转肽酶（GGT）水平高于非NASH组（分别为p = 0.223、p = 0.005和p = 0.006）。腹部超声对NAFLD诊断具有较高敏感性（与活检相比，超声检测脂肪变性分级的敏感性在1级为61%，2级为25%，3级为75%）。
结论
血清抵抗素可与其他非侵入性标志物联合使用，以预测NASH的存在，作为肝脏活检的替代方法。Hegazy M, Abo-Elfadl S, Mostafa A, Ibrahim M, Rashed L, Salman A. 肝脏活检中血清抵抗素水平及其受体基因表达作为非酒精性脂肪性肝病严重程度的预测指标。《欧亚肝脏胃肠病学杂志》2014年；4(2):59 - 62。
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