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伴有腹膜假黏液瘤的低级别阑尾黏液性肿瘤:病理学家的难题

Low Grade Appendiceal Mucinous Neoplasm with Pseudomyxoma Peritonei: An Enigma for Pathologist.

作者信息

Qadri Shagufta, Alam Kiran, Alam Feroz, Maheshwari Veena

机构信息

Department of Pathology, Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh, India.

出版信息

Euroasian J Hepatogastroenterol. 2014 Jul-Dec;4(2):113-116. doi: 10.5005/jp-journals-10018-1115. Epub 2014 Jul 28.

DOI:10.5005/jp-journals-10018-1115
PMID:29699361
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5913910/
Abstract

Malignant mucinous neoplasms of the appendix is an infrequently encountered entity. Extra-appendiceal spread of these tumor is one of the commonest etiology of pseudomyxoma peritonei, which demands a hightened vigilance in their early diagnosis. Although low-grade appendiceal mucinous neoplasms (LAMNs) largely stay confined to the appendix, but they can spread to the peritoneum as pseudomyxoma peritonei leading to an unpredictable outcome. Due to the rare occurrence of low-grade appendiceal neoplasm only tenuous and limited information is present in the medical literature. We report a case of LAMN with pseudomyxoma peritonei in a 45-year-old male, who presented with the complaints of abdominal distension associated with abdominal pain and constipation. Clinical examinations and computed tomography (CT) scan were suggestive of pseudomyxoma peritonei. Peroperative findings and histopathological examination rendered a conclusive diagnosis of low-grade appendiceal neoplasm. Qadri S, Alam K, Alam F, Maheshwari V. Low Grade Appendiceal Muci-nous Neoplasm with Pseudomyxoma Peritonei: An Enigma for Pathologist. Euroasian J Hepato-Gastroenterol 2014;4(2):113-116.

摘要

阑尾恶性黏液性肿瘤是一种较少见的疾病。这些肿瘤的阑尾外播散是腹膜假黏液瘤最常见的病因之一,这就要求在其早期诊断时提高警惕。尽管低级别阑尾黏液性肿瘤(LAMNs)大多局限于阑尾,但它们可作为腹膜假黏液瘤扩散至腹膜,导致不可预测的后果。由于低级别阑尾肿瘤罕见,医学文献中仅有微弱且有限的信息。我们报告一例45岁男性的LAMN伴腹膜假黏液瘤病例,该患者表现为腹胀伴腹痛和便秘。临床检查和计算机断层扫描(CT)提示腹膜假黏液瘤。手术所见和组织病理学检查确诊为低级别阑尾肿瘤。Qadri S, Alam K, Alam F, Maheshwari V. 低级别阑尾黏液性肿瘤伴腹膜假黏液瘤:病理学家的一个谜团。《欧亚肝脏胃肠病学杂志》2014年;4(2):113 - 116。

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本文引用的文献

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The incidence of benign and malignant neoplasia presenting as acute appendicitis.表现为急性阑尾炎的良性和恶性肿瘤的发生率。
Am Surg. 2010 Aug;76(8):808-11.
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Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence.阑尾黏液性肿瘤:116 例临床病理研究并分析复发相关因素。
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Analysis of loss of heterozygosity for tumor-suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix.
对肿瘤抑制基因杂合性缺失的分析能够准确地对阑尾黏液性肿瘤的临床行为进行分类和预测。
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Review of the pathological results of 2660 appendicectomy specimens.对2660份阑尾切除术标本的病理结果进行回顾。
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Pseudomyxoma peritonei of appendiceal origin: a clinicopathologic analysis of 101 patients uniformly treated at a single institution, with literature review.阑尾源性腹膜假黏液瘤:对在单一机构接受统一治疗的101例患者的临床病理分析,并附文献综述
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6
Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosis.伴有播散性腹膜腺黏液瘤病的腹膜假黏液瘤患者的预后明显优于腹膜黏液腺癌患者。
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8
Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to "pseudomyxoma peritonei".播散性腹膜腺黏液瘤病和腹膜黏液性癌病。109例临床病理分析,重点在于鉴别病理特征、起源部位、预后以及与“腹膜假黏液瘤”的关系。
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The histogenesis of mucinous cystadenoma of the appendix.阑尾黏液性囊腺瘤的组织发生
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