Hijona Jesús Joaquín, Carballo Antonio Luis, Sánchez María Soledad, Dyachkova Nataliya, Expósito Juan Francisco, Alcázar José Luis
a Department of Gynecology and Obstetrics , Complejo Hospitalario de Jaén , Jaén , Spain.
b Department of Otorhinolaryngology , Complejo Hospitalario de Jaén , Jaén , Spain.
J Matern Fetal Neonatal Med. 2019 Aug;32(16):2741-2745. doi: 10.1080/14767058.2018.1449196. Epub 2018 Apr 26.
To evaluate the efficacy and safety of dequalinium chloride (DQC; 10 mg vaginal tablets), administered shortly prior to delivery in women with group B streptococcus (GBS) infection.
This observational, longitudinal, and prospective study involved 201 pregnant women at term, potentially carriers of GBS bacteria, scheduled for induction with oxytocin and with no premature rupture of amniotic membranes.
A total of 163 women (81.09%) tested positive for GBS in their first vaginal swab (pre-DQC administration). In their second swab, post-DQC administration, 48 women were positive (23.88%) and 153 (76.12%) were negative. The number of GBS-colonized women after the administration of DQC was reduced by 57.21%. In the third swab, postpartum, 57 women were positive (28.35%). None of the newborns were positive for GBS in the oropharynx swab. The median DQC exposure time was 9.98 hours. Adverse events associated with the prophylactic treatment were reported in five women (vulvovaginal irritation).
The administration of a single vaginal tablet of 10 mg DQC the day before induction reduced the number of GBS-colonized women by 57.21%, causing no maternal and perinatal adverse events.
评估在分娩前短时间给予感染B族链球菌（GBS）的女性氯化喹啉（DQC；10毫克阴道片）的疗效和安全性。
这项观察性、纵向和前瞻性研究纳入了201名足月孕妇，她们可能是GBS细菌携带者，计划使用缩宫素引产且未发生胎膜早破。
共有163名女性（81.09%）在首次阴道拭子检查（DQC给药前）中GBS检测呈阳性。在DQC给药后的第二次拭子检查中，48名女性呈阳性（23.88%），153名（76.12%）呈阴性。给予DQC后GBS定植女性的数量减少了57.21%。在产后的第三次拭子检查中，57名女性呈阳性（28.35%）。没有新生儿的口咽拭子GBS检测呈阳性。DQC的中位暴露时间为9.98小时。有5名女性报告了与预防性治疗相关的不良事件（外阴阴道刺激）。
引产当天给予一片10毫克的DQC阴道片可使GBS定植女性的数量减少57.21%，且未引起母婴围产期不良事件。
