作为结构不稳定的I类核酶激活分子的多聚乙烯多胺的比较研究
Comparative study of polyethylene polyamines as activator molecules for a structurally unstable group I ribozyme.
作者信息
Gulshan Mst Ara, Matsumura Shigeyoshi, Higuchi Tsunehiko, Umezawa Naoki, Ikawa Yoshiya
机构信息
a Department of Chemistry, Graduate School of Science and Engineering , University of Toyama , Toyama , Japan.
b Graduate School of Innovative Life Science , University of Toyama , Toyama , Japan.
出版信息
Biosci Biotechnol Biochem. 2018 Aug;82(8):1404-1407. doi: 10.1080/09168451.2018.1465811. Epub 2018 Apr 26.
Polyamines are a promising class of molecules that can modulate RNA enzyme activities. To analyze the effects of the number of amine moieties systematically, we employed four polyamines sharing dimethylene units to connect amine moieties. As a model RNA enzyme, we used a structurally unstable group I ribozyme, which was activated most and least efficiently by tetraethylenepentamine and diethylenetriamine respectively.
多胺是一类很有前景的分子，能够调节RNA酶的活性。为了系统地分析胺基团数量的影响，我们使用了四种通过二亚甲基单元连接胺基团的多胺。作为模型RNA酶，我们采用了一种结构不稳定的I型核酶，它分别被五乙烯六胺和二乙烯三胺激活的效率最高和最低。
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