Roig M, Montserrat L, Gallart A
Department of Pediatrics, Hospital Infantil Vall d'Hebron, Autonomous University, Barcelona, Spain.
Pediatrics. 1988 Sep;82(3 Pt 2):492-5.
Five patients with a moderate to severe degree of nonhereditary chorea were successfully treated with standard anticonvulsant doses of carbamazepine. In two cases, the cause of chorea was related to a streptococcal infection. In another patient, the involuntary movements appeared seven days after severe head injury. The cause in the remaining two patients could not be determined with certainty, despite extensive laboratory investigations. Improvement began within four to 15 days after the initiation of therapy. No side effects were noticed in four patients throughout treatment (3 months to 36 months). In one patient, the medication had to be discontinued after 17 days, because of an allergic cutaneous rash. In view of our results, we propose that carbamazepine be considered as an alternative drug for the treatment of nonhereditary chorea.
五名患有中度至重度非遗传性舞蹈症的患者接受标准抗惊厥剂量的卡马西平治疗后取得成功。其中两例舞蹈症病因与链球菌感染有关。另一例患者在严重头部受伤七天后出现不自主运动。尽管进行了广泛的实验室检查，其余两名患者的病因仍无法确定。治疗开始后四至十五天内病情开始改善。四名患者在整个治疗期间（3个月至36个月）未出现副作用。一名患者在17天后因过敏性皮疹不得不停药。鉴于我们的研究结果，我们建议将卡马西平视为治疗非遗传性舞蹈症的替代药物。
