Leisch F
I. Medizinischen Abteilung, Allgemeinen Krankenhauses der Stadt Linz.
Acta Med Austriaca. 1988;15(2):51-7.
Thrombolytic therapy in acute myocardial infarction is able to recanalize thrombotic occluded infarct arteries in about 35 to 90%. The results depend on the thrombolytic agent and the route of administration (i.c., i.v.). Successful recanalization causes a reduction of hospital- and one year mortality and reduction of the infarct size in a close correlation to duration of ischemic pain at the beginning of thrombolysis. Significant residual stenoses persist in about 80 to 90% after successful reperfusion. In these patients, PTCA can be performed with high success rates and with a low incidence of complications. Successful PTCA is associated with a reduction of reinfarction and further improvement of left ventricular function. Thus, the value of thrombolysis in acute myocardial infarction in patients with pain duration shorter than 3 to 4 hours is established. The value and optimal point of time for performing PTCA after thrombolysis remains to be defined.
急性心肌梗死的溶栓治疗能够使约35%至90%的血栓闭塞梗死动脉再通。结果取决于溶栓剂和给药途径（即，静脉内、冠状动脉内）。成功再通可降低住院死亡率和一年死亡率，并缩小梗死面积，这与溶栓开始时缺血性疼痛的持续时间密切相关。成功再灌注后，约80%至90%的患者仍存在明显的残余狭窄。对于这些患者，PTCA（经皮冠状动脉腔内血管成形术）成功率高且并发症发生率低。成功的PTCA与再梗死率降低和左心室功能进一步改善相关。因此，疼痛持续时间短于3至4小时的急性心肌梗死患者溶栓治疗的价值已得到确立。溶栓后进行PTCA的价值和最佳时间点仍有待确定。
