Taha Nur Akmar, Ibrahim Mohamed Izham, Rahman Ab Fatah, Shafie Asrul Akmal, Rahman Abdul Hamid
Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
College of Pharmacy, Qatar University, Doha, Qatar.
Value Health Reg Issues. 2012 May;1(1):82-86. doi: 10.1016/j.vhri.2012.03.006. Epub 2012 May 25.
To explore the validity and reliability of a disease-specific health-related quality-of-life questionnaire-the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4)-in patients with schizophrenia in Malaysia.
A total of 222 outpatients with schizophrenia receiving treatment at the Universiti Kebangsaan Malaysia Medical Centre completed the SQLS-R4 in either the Malay or the English language. A generic self-report health-related quality-of-life measure-the EuroQoL group EuroQol five-dimensional questionnaire-and a measure of symptom severity-the Clinical Global Impression-Schizophrenia scale-were also administered to assess validity.
Good internal consistency reliability was found for both the psychosocial and vitality domains (Cronbach's α = 0.95 and 0.85, respectively). Most items were also significantly correlated with their own scale score (r ranging from 0.29 to 0.74). There was a moderate correlation between the SQLS-R4 "vitality" domain and the EuroQol five-dimensional questionnaire "usual activities" domain (r = 0.44) and a large correlation between the SQLS-R4 "psychosocial" domain and the EuroQol five-dimensional questionnaire "anxiety/depression" domain (r = 0.44-0.57). Most of the symptom dimensions of the Clinical Global Impression-Schizophrenia scale were also moderately correlated with the SQLS-R4 subscale scores.
The SQLS-R4 is a valid and reliable health-related quality-of-life instrument for use in minimally ill patients with schizophrenia in Malaysia, but some of the items may be redundant and irrelevant. Validation of SQLS-R4 in different types of patients and various levels of illness severity is required to further verify its application.
探讨一种特定疾病的健康相关生活质量问卷——精神分裂症生活质量量表修订版4（SQLS - R4）在马来西亚精神分裂症患者中的有效性和可靠性。
共有222名在马来西亚国民大学医学中心接受治疗的精神分裂症门诊患者用马来语或英语完成了SQLS - R4问卷。还使用了一种通用的自我报告健康相关生活质量测量工具——欧洲五维健康量表（EuroQoL）以及一种症状严重程度测量工具——临床总体印象 - 精神分裂症量表来评估有效性。
心理社会领域和活力领域均具有良好的内部一致性信度（Cronbach's α分别为0.95和0.85）。大多数项目也与其自身量表得分显著相关（r值范围为0.29至0.74）。SQLS - R4“活力”领域与欧洲五维健康量表“日常活动”领域之间存在中度相关性（r = 0.44），SQLS - R4“心理社会”领域与欧洲五维健康量表“焦虑/抑郁”领域之间存在高度相关性（r = 0.44 - 0.57）。临床总体印象 - 精神分裂症量表的大多数症状维度也与SQLS - R4子量表得分存在中度相关性。
SQLS - R4是一种有效且可靠的健康相关生活质量测量工具，可用于马来西亚病情较轻的精神分裂症患者，但部分项目可能冗余且不相关。需要在不同类型患者和不同疾病严重程度水平上对SQLS - R4进行验证，以进一步核实其应用。
