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静脉输注依泊二醇治疗慢性肝病患者的活性和耐受性初步报告

Preliminary report on activity and tolerability of epomediol, administered by intravenous infusion, in patients with chronic hepatopathies.

作者信息

Mazzeo F, Bernocchi D, Cavalli C, Manini G

机构信息

Gastroenterology and Endoscopy Centre, Borgonovo Val Tidone Hospital, Piacenza, Italy.

出版信息

J Int Med Res. 1988 May-Jun;16(3):237-43. doi: 10.1177/030006058801600312.

DOI:10.1177/030006058801600312
PMID:2970410
Abstract

The therapeutic activity and tolerability of epomediol were studied in 28 patients with chronic hepatopathies. Treatment was continued, parenterally, for 10 days (400-600 mg once daily by intravenous infusion). Clinical parameters (headache, right hypochondrial pain, bitter taste in the mouth, asthenia and nausea) and hepatic function (transaminase, alkaline phosphatase and gamma-glutamyl transpeptidase) showed significant improvements. Clinical and systemic tolerabilities of epomediol were satisfactory.

摘要

对28例慢性肝病患者研究了埃波二醇的治疗活性和耐受性。采用肠胃外给药方式持续治疗10天(通过静脉输注,每日一次,剂量为400 - 600毫克)。临床参数(头痛、右季肋部疼痛、口苦、乏力和恶心)及肝功能(转氨酶、碱性磷酸酶和γ-谷氨酰转肽酶)均有显著改善。埃波二醇的临床和全身耐受性良好。

相似文献

1
Preliminary report on activity and tolerability of epomediol, administered by intravenous infusion, in patients with chronic hepatopathies.静脉输注依泊二醇治疗慢性肝病患者的活性和耐受性初步报告
J Int Med Res. 1988 May-Jun;16(3):237-43. doi: 10.1177/030006058801600312.
2
Activity of epomediol in the treatment of hepatopathies: a double-blind multi-centre study.埃坡二醇治疗肝病的活性:一项双盲多中心研究。
J Int Med Res. 1987 May-Jun;15(3):134-47. doi: 10.1177/030006058701500303.
3
[Efficacy and tolerance of intravenously administered epomediol in patients with hepatopathy].[依泊二醇静脉给药对肝病患者的疗效及耐受性]
Clin Ter. 1988 Oct 15;127(1):37-41.
4
[Epomediol-induced modifications of the biohumoral picture in hepatic cirrhosis with or without cholestasis].[依泊二醇对伴有或不伴有胆汁淤积的肝硬化患者生物体液状况的影响]
Clin Ter. 1983 Feb 15;104(3):227-33.
5
[Epomediol treatment of fatty liver in alcohol abuse. A controlled clinical double-blind study].[依泊二醇治疗酒精滥用所致脂肪肝。一项对照临床双盲研究]
Clin Ter. 1985 Mar 31;112(6):527-35.
6
[Symptomatic effect of epomediol in patients with cholestasis of pregnancy].
Rev Med Chil. 1992 May;120(5):545-51.
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[Antilipemic activity of epomediol in patients with primary hyperlipidemia].[依泊二醇对原发性高脂血症患者的抗血脂活性]
Clin Ter. 1987 Jan 15;120(1):37-43.
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[Therapeutic effect of a new molecule, epomediol, in intrahepatic cholestasis].[一种新分子埃坡二醇治疗肝内胆汁淤积症的疗效]
Clin Ter. 1982 May 31;101(4):371-86.
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[Treatment of chronic bronchitic syndrome].[慢性支气管炎综合征的治疗]
Fortschr Med. 1973 Feb 22;91(6):259-61.
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[Therapeutic action of S-adenosylmethionine in some chronic hepatopathies].[S-腺苷甲硫氨酸在某些慢性肝病中的治疗作用]
Minerva Med. 1975 May 2;66(33):1563-70.

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