Lv Jiapei, Zhang Linlin, Yan Furong, Wang Xiangdong
Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical School, Shanghai Institute of Clinical Bioinformatics, Shanghai, China.
Clin Transl Med. 2018 Apr 27;7(1):12. doi: 10.1186/s40169-018-0190-9.
Lipidomics is a measurement of a large scale of lipid species to understand roles of their carbon atoms, dual bonds, or isomerism in the lipid molecule. Clinical lipidomics was recently defined "as a new integrative biomedicine to discover the correlation and regulation between a large scale of lipid elements measured and analyzed in liquid biopsies from patients with those patient phenomes and clinical phenotypes". The first step to translate lipidomics into clinical lipidomics is to settle a number of standard operation procedures and protocols of lipidomics performance and measurement. Clinical lipidomics is the part of clinical trans-omics which was coined as a new emerging scientific discipline where clinical phenomes are integrated with molecular multiomics. We believe it is the time to translate lipid science and lipidomics into clinical application and to understand the importance of clinical lipidomics as one of the most helpful approaches during the design and decision-making of therapeutic strategies for individuals. We emphasize here that clinical lipidomics should be merged with clinical phenomes, e.g. patient signs and symptoms, biomedical analyses, pathology, images, and responses to therapies, although it is difficult to integrate and fuse the information of clinical lipidomics with clinical phenomes. It will be a great achievement if we can draw the networks of lipidomic species fused with networks of genes and proteins to describe the molecular mechanisms of the disease in multi-dimensions.
脂质组学是对大规模脂质种类的测量，以了解其碳原子、双键或异构体在脂质分子中的作用。临床脂质组学最近被定义为“一种新的综合生物医学，用于发现从患者液体活检中测量和分析的大规模脂质成分与这些患者表型和临床表型之间的相关性和调控关系”。将脂质组学转化为临床脂质组学的第一步是确定一些脂质组学性能和测量的标准操作程序和方案。临床脂质组学是临床跨组学的一部分，临床跨组学是一门新兴的科学学科，它将临床表型与分子多组学整合在一起。我们认为，现在是将脂质科学和脂质组学转化为临床应用的时候了，并且要认识到临床脂质组学作为个体治疗策略设计和决策过程中最有用的方法之一的重要性。我们在此强调，临床脂质组学应与临床表型相结合，例如患者的体征和症状、生物医学分析、病理学、图像以及对治疗的反应，尽管将临床脂质组学信息与临床表型进行整合和融合很困难。如果我们能够绘制出与基因和蛋白质网络融合的脂质组学物种网络，以多维方式描述疾病的分子机制，那将是一项巨大的成就。
