Department of Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology, Islamabad, Pakistan.
Department of Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology, Islamabad, Pakistan.
J Theor Biol. 2018 Aug 14;451:1-9. doi: 10.1016/j.jtbi.2018.04.032. Epub 2018 Apr 26.
The Physiologically based pharmacokinetic (PBPK) modeling is a supporting tool in drug discovery and improvement. Simulations produced by these models help to save time and aids in examining the effects of different variables on the pharmacokinetics of drugs. For this purpose, Sheila and Peters suggested a PBPK model capable of performing simulations to study a given drug absorption. There is a need to extend this model to the whole body entailing all another process like distribution, metabolism, and elimination, besides absorption. The aim of this scientific study is to hypothesize a WB-PBPK model through integrating absorption, distribution, metabolism, and elimination processes with the existing PBPK model.Absorption, distribution, metabolism, and elimination models are designed, integrated with PBPK model and validated. For validation purposes, clinical records of few drugs are collected from the literature. The developed WB-PBPK model is affirmed by comparing the simulations produced by the model against the searched clinical data. . It is proposed that the WB-PBPK model may be used in pharmaceutical industries to create of the pharmacokinetic profiles of drug candidates for better outcomes, as it is advance PBPK model and creates comprehensive PK profiles for drug ADME in concentration-time plots.
生理药代动力学（PBPK）模型是药物发现和改进的辅助工具。这些模型产生的模拟有助于节省时间，并有助于检查不同变量对药物药代动力学的影响。为此，Sheila 和 Peters 提出了一种能够进行模拟以研究特定药物吸收的 PBPK 模型。需要将该模型扩展到全身，除了吸收之外，还包括分布、代谢和消除等所有其他过程。这项科学研究的目的是通过将吸收、分布、代谢和消除过程与现有的 PBPK 模型相结合，假设一个 WB-PBPK 模型。设计、整合吸收、分布、代谢和消除模型，并对其进行验证。为了验证目的，从文献中收集了一些药物的临床记录。通过将模型产生的模拟与搜索到的临床数据进行比较，对开发的 WB-PBPK 模型进行了验证。提出 WB-PBPK 模型可用于制药行业，为药物候选物创建药代动力学曲线，以获得更好的结果，因为它是一种先进的 PBPK 模型，可以在浓度-时间图中为药物 ADME 创建全面的 PK 曲线。
