西番莲属植物在动物模型中抗溃疡活性的细胞保护、抗氧化和抗炎机制。
Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models.
机构信息
Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Universidade Federal da Paraíba (UFPB), João Pessoa 58051-970, PB, Brazil.
Department of Biophysics and Pharmacology and Department of Morphology, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil.
出版信息
J Ethnopharmacol. 2018 Aug 10;222:190-200. doi: 10.1016/j.jep.2018.04.019. Epub 2018 Apr 25.
ETHNOPHARMACOLOGICAL RELEVANCE
The leaves and roots of Cissampelos sympodialis (Menispermaceae) are used by indian tribes and in folk medicine to treat genitourinary infections, inflammation, asthma and gastrointestinal disorders.
MATERIAL AND METHODS
The standardized ethanolic extract (Cs-EtOHE) and alkaloids total fraction (Cs-TAF) obtained from aerial parts of C. sympodialis were evaluated in several models of acute gastric ulcers. The antisecretory and/or neutralizing mechanisms of the gastric acid secretion, cytoprotective, antioxidant and immunoregulatory mechanisms were also evaluated.
RESULTS
Cs-EtOHE and Cs-TAF presented a reduction in gastric mucosa lesions against ethanol, NSAIDs, hypothermic restraint-stress and gastric juice containment induced ulcer models. This activity is related to alkaloids present in the extract, and involves the participation of sulfhydryl compounds, nitric oxide, K channels, prostaglandins, decreased levels of IL-1β and TNF-α and increased levels of GSH and IL-10.
CONCLUSION
The data indicate gastroprotective activity, due to the participation of the cytoprotective, antioxidant and immunoregulatory mechanisms.
民族药理学相关性
印度部落和民间医学中使用印度防己藤（防己科）的叶子和根来治疗泌尿生殖系统感染、炎症、哮喘和胃肠道疾病。
材料和方法
从印度防己藤的地上部分获得的标准化乙醇提取物（Cs-EtOHE）和总生物碱部分（Cs-TAF）在几种急性胃溃疡模型中进行了评估。还评估了胃酸分泌的抗分泌和/或中和机制、细胞保护、抗氧化和免疫调节机制。
结果
Cs-EtOHE 和 Cs-TAF 对乙醇、非甾体抗炎药、低温束缚应激和胃液保留诱导的溃疡模型中的胃粘膜损伤有减少作用。这种活性与提取物中的生物碱有关，涉及巯基化合物、一氧化氮、K 通道、前列腺素的参与，降低了 IL-1β 和 TNF-α 的水平，增加了 GSH 和 IL-10 的水平。
结论
数据表明由于细胞保护、抗氧化和免疫调节机制的参与，具有胃保护活性。
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