Jilg W, Schmidt M, Deinhardt F
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, University of Munich, F.R.G.
J Hepatol. 1988 Apr;6(2):201-7. doi: 10.1016/s0168-8278(88)80032-1.
Antibody levels to hepatitis B surface antigen (anti-HBs) in healthy adults vaccinated with three doses of plasma-derived hepatitis B vaccine, containing 20, 10 or 5 micrograms of antigen, were followed for 4-6 years. After vaccination, 1034 of 1076 individuals had developed anti-HBs and 1016 had antibody concentrations above 10 IU/l. 681 of all initial responders could be tested after 1 year, 520 after 2, 380 after 3 and 213 after 4 years. 72 and 39 individuals, respectively, of the 185 earliest vaccinated volunteers were available for retesting after 5 and 6 years. Four years after the first vaccination, anti-HBs levels in 34% had dropped below 10 IU/l. The persistence of anti-HBs above this value depended on the peak antibody response after the third vaccination. Whereas all vaccinees tested with peak anti-HBs levels above 10,000 IU/l still had levels above 10 IU/l after 6 years, no-one with initial values between 10 and 100 IU/l maintained antibody concentrations above 10 IU/l for longer than 4 years. The rate of decrease in anti-HBs was independent of the peak anti-HBs value, the vaccine dose, and the age and sex of the vaccinees.
对接种了三剂含20微克、10微克或5微克抗原的血浆源性乙肝疫苗的健康成年人，随访其乙肝表面抗原抗体水平（抗-HBs）4至6年。接种疫苗后，1076名个体中有1034人产生了抗-HBs，1016人的抗体浓度高于10 IU/l。所有初始应答者中，681人在1年后接受检测，520人在2年后，380人在3年后，213人在4年后接受检测。185名最早接种疫苗的志愿者中，分别有72人和39人在5年和6年后可接受重新检测。首次接种疫苗4年后，34%的人的抗-HBs水平降至10 IU/l以下。抗-HBs高于此值的持续情况取决于第三次接种后的抗体峰值反应。所有抗-HBs峰值水平高于10000 IU/l的受测接种者在6年后其水平仍高于10 IU/l，而初始值在10至100 IU/l之间的人，没有一个人的抗体浓度高于10 IU/l的时间超过4年。抗-HBs的下降速率与抗-HBs峰值、疫苗剂量以及接种者的年龄和性别无关。
