Miyawaki S, Nakamura Y, Takeshita T, Yoshida H, Shibata Y, Mitsuoka S
Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
Lab Anim Sci. 1988 Jun;38(3):266-72.
MRL-lpr, Yaa males were developed by the transfer of the Yaa gene from BXSB males to the MRL-lpr strain. The early-onset autoimmune disease of MRL-lpr males was accelerated further by the action of Yaa. All the serological parameters of autoimmune disease examined, i.e., anti-DNA antibodies, rheumatoid factors and circulating immune complexes were elevated earlier in MRL-lpr, Yaa males than in MRL-lpr males. Consequently, the MRL-lpr, Yaa males showed the clinical signs of an earlier and more rapidly progressive glomerulonephritis as compared with MRL-lpr males. The lifespan of MRL-lpr, Yaa males was shortened by about 50% in comparison to MRL-lpr males, with 90% of MRL-lpr, Yaa males dead by about 4 months of age. The clinical features and overall intensity of the autoimmune responses in the terminal stages appeared to be similar in both MRL-lpr, Yaa and MRL-lpr males. Thus, Yaa appeared merely to accelerate the disease course of MRL-lpr males, without altering the essential nature of the disease.
MRL-lpr、Yaa雄性小鼠是通过将Yaa基因从BXSB雄性小鼠转移到MRL-lpr品系而培育出来的。Yaa的作用进一步加速了MRL-lpr雄性小鼠的早发性自身免疫性疾病。在检测的自身免疫性疾病的所有血清学参数中，即抗DNA抗体、类风湿因子和循环免疫复合物，MRL-lpr、Yaa雄性小鼠比MRL-lpr雄性小鼠更早升高。因此，与MRL-lpr雄性小鼠相比，MRL-lpr、Yaa雄性小鼠表现出更早且进展更快的肾小球肾炎的临床症状。与MRL-lpr雄性小鼠相比，MRL-lpr、Yaa雄性小鼠的寿命缩短了约50%，90%的MRL-lpr、Yaa雄性小鼠在约4月龄时死亡。在终末期，MRL-lpr、Yaa雄性小鼠和MRL-lpr雄性小鼠的临床特征和自身免疫反应的总体强度似乎相似。因此，Yaa似乎只是加速了MRL-lpr雄性小鼠的病程，而没有改变疾病的本质。
