胸腺主要组织相容性复合体抗原和αβ T细胞受体决定T细胞的CD4/CD8表型。
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.
作者信息
Teh H S, Kisielow P, Scott B, Kishi H, Uematsu Y, Blüthmann H, von Boehmer H
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
Nature. 1988 Sep 15;335(6187):229-33. doi: 10.1038/335229a0.
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.
在表达从一个雄性特异性、H-2Db限制性CD4-8+ T细胞克隆分离的α和β T细胞受体基因的T细胞受体转基因小鼠中，分析了T细胞受体和T细胞亚群。结果表明，未成熟胸腺细胞上的T细胞受体与胸腺主要组织相容性复合体抗原的特异性相互作用决定了CD4+8+胸腺细胞分化为CD4+8-或CD4-8+成熟T细胞。
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