Department of Cardiovascular Medicine, Juntendo University, Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Cardiovascular Medicine, Juntendo University, Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Int J Cardiol. 2018 Jul 1;262:92-98. doi: 10.1016/j.ijcard.2018.02.039.
No nutritional index has been firmly established yet in patients with coronary artery disease (CAD). In this study, we propose a simple to calculate nutritional indicator in patients who underwent percutaneous coronary intervention (PCI) by using parameters routinely measured in CAD and evaluated its prognostic implication.
This study is a retrospective observational analysis of a prospective database. The subjects were consecutive 3567 patients underwent their first PCI between 2000 and 2013 at Juntendo University Hospital in Tokyo. The median of the follow-up period was 6.3 years (range: 0-13.6 years). The novel nutritional index was calculated by the formula; Triglycerides (TG) × Total Cholesterol (TC) × Body Weight (BW) Index (TCBI) = TG × TC × BW / 1000 (TG and TC: mg/dl, and BW: kg).
The Spearman non-parametric correlation coefficient between TCBI and the most often used conventional nutritional index, Geriatric Nutritional Risk Index (GNRI), was 0.355, indicating modest correlation. Moreover, Unadjusted Kaplan-Meier analysis showed higher all-cause mortality, cardiovascular mortality, and cancer mortality in patients with low TCBI. Consistently, elevation of TCBI was associated with reduced all-cause (hazard ratio: 0.86, 95%CI: 0.77-0.96, p < 0.001), cardiovascular (0.78, 0.66-0.92, p = 0.003), and cancer mortality (0.76, 0.58-0.99, p = 0.041) in patients after PCI by multivariate Cox proportional hazard analyses.
TCBI, a novel and easy to calculate nutrition index, is a useful prognostic indicator in patients with CAD.
在冠心病（CAD）患者中，尚未确定明确的营养指标。本研究通过使用 CAD 常规测量的参数来计算接受经皮冠状动脉介入治疗（PCI）的患者的易于计算的营养指标，并评估其预后意义。
这是一项对前瞻性数据库进行的回顾性观察性分析。研究对象为 2000 年至 2013 年期间在东京顺天堂大学医院接受首次 PCI 的连续 3567 例患者。中位随访时间为 6.3 年（范围：0-13.6 年）。新的营养指数通过公式计算；甘油三酯（TG）×总胆固醇（TC）×体重（BW）指数（TCBI）= TG×TC×BW/1000（TG 和 TC：mg/dl，BW：kg）。
TCBI 与最常用的常规营养指数，老年营养风险指数（GNRI）之间的斯皮尔曼非参数相关系数为 0.355，表明中度相关。此外，未经调整的 Kaplan-Meier 分析显示 TCBI 较低的患者全因死亡率、心血管死亡率和癌症死亡率较高。同样，TCBI 升高与 PCI 后全因（风险比：0.86，95%CI：0.77-0.96，p<0.001）、心血管（0.78，0.66-0.92，p=0.003）和癌症死亡率（0.76，0.58-0.99，p=0.041）降低相关，采用多变量 Cox 比例风险分析。
TCBI 是一种新的易于计算的营养指数，是 CAD 患者有用的预后指标。
