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PD-1 Inhibitors in the Advanced Esophageal Cancer.晚期食管癌中的程序性死亡受体1(PD-1)抑制剂
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Basis for molecular diagnostics and immunotherapy for esophageal cancer.食管癌分子诊断与免疫治疗的基础。
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Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model.在食管腺癌模型中,使用STING激动剂ADU-S100进行瘤内免疫治疗可诱导CD8 + T细胞介导的抗肿瘤免疫。
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Platelet-to-lymphocyte ratio is an independent predictor of chemoradiotherapy-related esophageal fistula in esophageal cancer patients.血小板与淋巴细胞比值是食管癌患者放化疗相关食管瘘的独立预测指标。
Ann Transl Med. 2020 Sep;8(18):1163. doi: 10.21037/atm-20-4053.
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CheckMate-032 Study: promising efficacy with nivolumab-based immunotherapy in pretreated esophagogastric cancer.CheckMate-032研究:基于纳武单抗的免疫疗法在经治食管胃癌中显示出有前景的疗效。
J Thorac Dis. 2019 Mar;11(Suppl 3):S394-S395. doi: 10.21037/jtd.2018.12.02.

本文引用的文献

1
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial.纳武利尤单抗治疗既往至少两种化疗方案治疗失败或不耐受的晚期胃或胃食管结合部腺癌患者(ONO-4538-12,ATTRACTION-2):一项随机、双盲、安慰剂对照、III 期临床试验。
Lancet. 2017 Dec 2;390(10111):2461-2471. doi: 10.1016/S0140-6736(17)31827-5. Epub 2017 Oct 6.
2
The Dynamic and Transient Immune Microenvironment in Locally Advanced Esophageal Adenocarcinoma Post Chemoradiation.局部晚期食管腺癌放化疗后动态和瞬态免疫微环境。
Ann Surg. 2018 Dec;268(6):992-999. doi: 10.1097/SLA.0000000000002410.
3
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.错配修复缺陷可预测实体瘤对程序性死亡受体1(PD-1)阻断疗法的反应。
Science. 2017 Jul 28;357(6349):409-413. doi: 10.1126/science.aan6733. Epub 2017 Jun 8.
4
Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial.纳武利尤单抗治疗食管鳞癌:一项开放标签、多中心、2 期临床试验。
Lancet Oncol. 2017 May;18(5):631-639. doi: 10.1016/S1470-2045(17)30181-X. Epub 2017 Mar 15.
5
Integrated genomic characterization of oesophageal carcinoma.食管癌的综合基因组特征分析
Nature. 2017 Jan 12;541(7636):169-175. doi: 10.1038/nature20805. Epub 2017 Jan 4.
6
Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial.帕博利珠单抗治疗 PD-L1 阳性晚期胃癌患者(KEYNOTE-012):一项多中心、开放标签、Ib 期临床试验。
Lancet Oncol. 2016 Jun;17(6):717-726. doi: 10.1016/S1470-2045(16)00175-3. Epub 2016 May 3.
7
Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers.爱泼斯坦-巴尔病毒感染的胃癌中PD-L1表达丰富。
Oncotarget. 2016 May 31;7(22):32925-32. doi: 10.18632/oncotarget.9076.
8
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.克隆性新抗原引发T细胞免疫反应性以及对免疫检查点阻断的敏感性。
Science. 2016 Mar 25;351(6280):1463-9. doi: 10.1126/science.aaf1490. Epub 2016 Mar 3.
9
Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma.胃腺癌中PD-L1表达模式、CD8 T细胞浸润及相关免疫基质
Gut. 2017 May;66(5):794-801. doi: 10.1136/gutjnl-2015-310839. Epub 2016 Jan 22.
10
A clinical development paradigm for cancer vaccines and related biologics.癌症疫苗及相关生物制品的临床开发模式。
J Immunother. 2007 Jan;30(1):1-15. doi: 10.1097/01.cji.0000211341.88835.ae.

Single agent anti PD-1 inhibitors in esophageal cancer-a first step in a new therapeutic direction.

作者信息

Walsh Elaine M, Kelly Ronan J

机构信息

Upper Aerodigestive Malignancies Division, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

出版信息

J Thorac Dis. 2018 Mar;10(3):1308-1313. doi: 10.21037/jtd.2018.03.43.

DOI:10.21037/jtd.2018.03.43
PMID:29707283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5906338/
Abstract
摘要