Kelleci Ulker Anadol, Calhan Turan, Sahin Abdurrahman, Aydin-Ozemir Zeynep, Kahraman Resul, Ozdil Kamil, Sokmen Haci Mehmet, Yalcin Ayse Destina
1 University of Health Sciences, Umraniye, Istanbul, Turkey.
Clin EEG Neurosci. 2019 Mar;50(2):129-133. doi: 10.1177/1550059418767589. Epub 2018 Apr 30.
Crohn's Disease (CD) is a chronic systemic inflammatory disease associated with various extraintestinal manifestations, including seizure as a neurological finding. In this study, the prevalence of seizure and electroencephalographic abnormalities in patients with CD was investigated.
This study involved 41 patients with CD (female/male: 25/16) and 39 subjects in the control group (female/male: 25/14). Patients in the CD group were diagnosed and monitored according to the European Crohn's and Colitis Organization diagnostic criteria. The control group was composed of healthy subjects with similar age and sex as the CD group. Seizures were classified according to the criteria of the International League Against Epilepsy. Electroencephalography (EEG) was performed for all patients with CD and for healthy subjects. Seizure prevalence and EEG findings were also compared.
One patient in the CD group had history of seizures. EEG abnormality was significantly higher in the CD group (16/41, 39%) ( P = .001). The most common EEG abnormality was intermittent generalized slow wave abnormality in theta frequency.
Our study indicated that CD was associated with EEG abnormalities rather than seizure. The results also indicated that EEG was a potential indicator for detecting subclinical neurological abnormalities in CD.
克罗恩病（CD）是一种慢性全身性炎症性疾病，与多种肠外表现相关，包括癫痫发作作为一种神经学表现。在本研究中，对CD患者中癫痫发作和脑电图异常的患病率进行了调查。
本研究纳入41例CD患者（女性/男性：25/16）和39名对照组受试者（女性/男性：25/14）。CD组患者根据欧洲克罗恩病和结肠炎组织的诊断标准进行诊断和监测。对照组由年龄和性别与CD组相似的健康受试者组成。癫痫发作根据国际抗癫痫联盟的标准进行分类。对所有CD患者和健康受试者进行脑电图（EEG）检查。还比较了癫痫发作患病率和EEG结果。
CD组中有1例患者有癫痫发作史。CD组的EEG异常显著更高（16/41，39%）（P = .001）。最常见的EEG异常是θ频率的间歇性广泛性慢波异常。
我们的研究表明，CD与EEG异常而非癫痫发作相关。结果还表明，EEG是检测CD亚临床神经学异常的一个潜在指标。
