a Strategic Center for Diabetes Research, College of Medicine , King Saud University , Riyadh , Saudi Arabia.
b College of Medicine , King Saud University , Riyadh , Saudi Arabia.
Postgrad Med. 2018 May;130(4):402-408. doi: 10.1080/00325481.2018.1469370. Epub 2018 May 8.
This observational cross-sectional study aimed to investigate the relationship between serum Angiopoietin-2 (Ang-2) levels and cardiovascular (CVD) risk factors in drug controlled hypertensive diabetic subjects without cardiovascular complications.
All subjects were evaluated for fasting blood glucose (FBG), HbA1c, liver enzymes, lipid profile and serum Ang-2.
Mean serum Ang-2 level was significantly higher in hypertensive diabetic subjects. In bivariate analysis in diabetic subjects with cardiovascular risk factors, Ang-2 positively correlated with waist circumference, body mass index (BMI), systolic blood pressure (SBP), FBG, HbA1c and triglycerides. In multivariate linear regression analysis, this association remained significant with FBG and triglycerides. Ang-2 levels were independently associated with CVD risk factors in drug controlled Type 2 diabetes (T2D) subjects.
Further detailed studies in larger population with more attention is needed to consider Ang-2 level as a tool for CVD risk stratification in hypertensive diabetic subjects.
本观察性横断面研究旨在探讨血清血管生成素-2（Ang-2）水平与无心血管并发症的药物控制高血压糖尿病患者心血管（CVD）危险因素之间的关系。
所有受试者均进行空腹血糖（FBG）、糖化血红蛋白（HbA1c）、肝功能、血脂和血清 Ang-2 评估。
高血压糖尿病患者的平均血清 Ang-2 水平明显升高。在伴有心血管危险因素的糖尿病患者的双变量分析中，Ang-2 与腰围、体重指数（BMI）、收缩压（SBP）、FBG、HbA1c 和甘油三酯呈正相关。在多元线性回归分析中，这种相关性与 FBG 和甘油三酯仍有显著相关性。Ang-2 水平与药物控制 2 型糖尿病（T2D）患者的 CVD 危险因素独立相关。
需要在更大的人群中进行更详细的研究，并更多地关注 Ang-2 水平，将其作为高血压糖尿病患者 CVD 风险分层的工具。
