1Department of Nutrition,School of Public Health,University of São Paulo,São Paulo,Brazil.
2The Centre for Longitudinal Research - He Ara ki Mua,School of Population Health (Building 730, Level 3),Tamaki Campus,University of Auckland,261 Morrin Road,St Johns,Auckland 1072,New Zealand.
Public Health Nutr. 2018 Aug;21(12):2183-2192. doi: 10.1017/S1368980018000836. Epub 2018 Apr 30.
To evaluate the sociodemographic and lifestyle factors associated with insufficient and excessive use of folic acid supplements (FAS) among pregnant women.
A pregnancy cohort to which multinomial logistic regression models were applied to identify factors associated with duration and dose of FAS use.
The Growing Up in New Zealand child study, which enrolled pregnant women whose children were born in 2009-2010.
Pregnant women (n 6822) enrolled into a nationally generalizable cohort.
Ninety-two per cent of pregnant women were not taking FAS according to the national recommendation (4 weeks before until 12 weeks after conception), with 69 % taking insufficient FAS and 57 % extending FAS use past 13 weeks' gestation. The factors associated with extended use differed from those associated with insufficient use. Consistent with published literature, the relative risks of insufficient use were increased for younger women, those with less education, of non-European ethnicities, unemployed, who smoked cigarettes, whose pregnancy was unplanned or who had older children, or were living in more deprived households. In contrast, the relative risks of extended use were increased for women of higher socio-economic status or for whom this was their first pregnancy and decreased for women of Pacific v. European ethnicity.
In New Zealand, current use of FAS during pregnancy potentially exposes pregnant women and their unborn children to too little or too much folic acid. Further policy development is necessary to reduce current socio-economic inequities in the use of FAS.
评估与孕妇叶酸补充剂(FAS)使用不足和过量相关的社会人口学和生活方式因素。
应用多项逻辑回归模型的妊娠队列,以确定与 FAS 使用持续时间和剂量相关的因素。
新西兰儿童成长研究,该研究招募了 2009-2010 年出生的孩子的孕妇。
纳入一项全国性可推广队列的孕妇(n=6822)。
92%的孕妇未按照国家建议(受孕前 4 周至受孕后 12 周)服用 FAS,其中 69%服用的 FAS 不足,57%将 FAS 的使用时间延长至 13 周妊娠后。与使用不足相关的因素与与使用过量相关的因素不同。与已发表的文献一致,年轻女性、受教育程度较低、非欧洲族裔、失业、吸烟、计划外怀孕或有较大孩子、或生活在较贫困家庭的孕妇,使用不足的相对风险增加。相比之下,使用过量的相对风险增加与社会经济地位较高的妇女有关,或与这是她们第一次怀孕有关,而与太平洋族裔妇女相比,欧洲族裔妇女的相对风险降低。
在新西兰,目前孕妇在怀孕期间使用 FAS 可能使孕妇及其未出生的孩子暴露于过少或过多的叶酸之下。需要进一步制定政策,以减少目前使用 FAS 方面存在的社会经济不平等现象。