Bronchoconstriction by nebulized metabisulfite solutions (SO2) and its modification by ipratropium bromide.
作者信息
Seale J P, Temple D M, Tennant C M
机构信息
Department of Pharmacology, University of Sydney, New South Wales, Australia.
出版信息
Ann Allergy. 1988 Sep;61(3):209-13.
PMID:2970816
Abstract
A nebulized solution of sodium metabisulfite (MBS) induced bronchoconstriction in nine subjects with asthma. An anticholinergic drug, ipratropium bromide (IPRA), in doses (500 to 700 micrograms) which were found to inhibit methacholine-induced bronchoconstriction, protected three of the nine subjects against nebulized MBS. These results suggest that both cholinergic and non-cholinergic reflex mechanisms are involved in MBS-induced bronchoconstriction.
摘要
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