Robillard J E, Nakamura K T
Department of Pediatrics, University of Iowa College of Medicine, Iowa City.
Biol Neonate. 1988;53(4):201-11. doi: 10.1159/000242792.
The present review summarizes current and new knowledge concerning the major hormonal systems that directly or indirectly affect renal function during development. The role of the renin-angiotensin-aldosterone system in regulating renal function during fetal and postnatal life is reviewed. A summary of the role of this system during fetal and postnatal stresses is also provided. The physiological role of the renal kallikrein-kinin system in the control of renal blood flow, renin release and sodium excretion during development is examined. Possible influences of the prostaglandin system on regulation of renal function and renin secretion during fetal and postnatal maturation are explored. The effect of vasopressin on the ability of the fetal and postnatal kidney to concentrate urine and regulate body fluid homeostasis is reviewed in detail. The physiologic action of vasotocin on renal sodium and water homeostasis is described. New information regarding the role of the sympathetic system in the regulation of renal hemodynamics and in the control of renal function during development is presented. Finally, recent studies demonstrating the effect of atrial natriuretic factor and corticosteroids on the developing kidney are discussed.
本综述总结了有关在发育过程中直接或间接影响肾功能的主要激素系统的现有知识和新知识。综述了肾素 - 血管紧张素 - 醛固酮系统在胎儿期和出生后调节肾功能中的作用。还提供了该系统在胎儿期和出生后应激期间作用的总结。研究了肾激肽释放酶 - 激肽系统在发育过程中控制肾血流量、肾素释放和钠排泄的生理作用。探讨了前列腺素系统在胎儿期和出生后成熟过程中对肾功能调节和肾素分泌的可能影响。详细综述了血管加压素对胎儿期和出生后肾脏浓缩尿液及调节体液平衡能力的影响。描述了血管紧张素对肾钠和水平衡的生理作用。介绍了有关交感神经系统在发育过程中调节肾血流动力学和控制肾功能作用的新信息。最后，讨论了近期证明心房利钠因子和皮质类固醇对发育中肾脏影响的研究。
