Diabet Med. 1988 Jul-Aug;5(5):444-8.
In 713 newly diagnosed Caucasian diabetic patients aged 25-65 inclusive, insulin sensitivity and islet B-cell function were estimated from fasting plasma glucose and insulin concentrations by Homeostasis Model Assessment. Insulin sensitivity was reduced in obese subjects. It was also slightly lower in male than in female diabetic patients, in those who were sedentary and in those with high fasting plasma glucose concentrations. The estimated B-cell function was particularly impaired in patients with a high fasting plasma glucose and in those with normal rather than excess body weight. Whilst diabetes can present in normal weight patients with marked deficiency of B-cell function, presenting patients often have only a moderate impairment of B-cell function with markedly impaired insulin sensitivity secondary to obesity, physical inactivity, or being male.
在713例年龄在25至65岁（含）的新诊断白种糖尿病患者中，通过稳态模型评估，根据空腹血糖和胰岛素浓度估算胰岛素敏感性和胰岛B细胞功能。肥胖受试者的胰岛素敏感性降低。在男性糖尿病患者、久坐不动的患者以及空腹血糖浓度高的患者中，胰岛素敏感性也略低于女性糖尿病患者。空腹血糖高的患者以及体重正常而非超重的患者，其估算的B细胞功能尤其受损。虽然糖尿病可出现在B细胞功能明显缺乏的体重正常患者中，但就诊患者往往只有中度的B细胞功能损害，同时因肥胖、缺乏运动或男性因素导致胰岛素敏感性明显受损。
