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年轻女性性腺毒性治疗中生育力保存的临床实践指南:方法学质量和内容的概述和批判性评价。

Clinical practice guidelines for fertility preservation in young women undergoing gonadotoxic treatment: an overview and critical appraisal of methodological quality and content.

机构信息

Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.

Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.

出版信息

Reprod Biomed Online. 2018 Jul;37(1):60-70. doi: 10.1016/j.rbmo.2018.03.022. Epub 2018 Apr 13.

DOI:10.1016/j.rbmo.2018.03.022
PMID:29709394
Abstract

RESEARCH QUESTION

What is the methodological quality and content of internationally available clinical practice guidelines (CPGs) on fertility preservation (FP) care in adult women?

DESIGN

Internationally available CPGs on FP care in adult women were identified after conducting an extensive literature search and consulting (inter)national key experts. The methodological quality of the CPGs was appraised by an (inter)national panel of experts using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. The content of the best CPGs, scoring ≥60% for the domain 'Rigour of development' of the AGREE II instrument, was extracted and categorized according to their topic.

RESULTS

Thirty of the 1808 documents found were included. After consulting (inter)national key experts, 30 CPGs were included, six of which scored ≥60% for their 'Rigour of development'. The number of FP-related topics discussed by these six CPGs ranged from 4 to 12. The number of recommendations provided by the CPGs on these topics varied. The number of topics to which ≥5 recommendations were dedicated ranged from 0 to 4 between CPGs.

CONCLUSION

CPGs on the subject of FP care are available, but there is room for improvement in quality and content. Although written for use in daily practice, the CPGs can also be used to develop quality indicators to monitor the quality of current FP care or to evaluate future improvement initiatives.

摘要

研究问题

国际上现有的关于成年女性生育力保护(FP)护理的临床实践指南(CPGs)的方法学质量和内容如何?

设计

在进行广泛的文献检索并咨询(国际)关键专家后,确定了关于成年女性 FP 护理的国际 CPG。使用评估指南研究与评价(AGREE)II 工具,由(国际)专家组评估 CPG 的方法学质量。对 AGREE II 工具“制定的严谨性”域得分≥60%的最佳 CPG 的内容进行提取,并根据其主题进行分类。

结果

在 1808 篇文献中,有 30 篇入选。在咨询(国际)关键专家后,共纳入 30 项 CPG,其中 6 项在“制定的严谨性”方面得分≥60%。这 6 项 CPG 讨论的 FP 相关主题数量从 4 个到 12 个不等。CPG 就这些主题提供的建议数量各不相同。对这些主题中的≥5 个主题提供建议的 CPG 数量从 0 到 4 个不等。

结论

关于 FP 护理的 CPG 是可用的,但在质量和内容方面仍有改进的空间。尽管这些 CPG 是为日常实践而编写的,但也可以用于制定质量指标,以监测当前 FP 护理的质量,或评估未来的改进举措。

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