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Microsomal effects of cyproterone acetate and flutamide in rat testis.

作者信息

Clos V, Esteve A, Jane F, Salva P

机构信息

Departament de Farmacologia i Psiquiatria, Universitat Autõnoma de Barcelona, Bellaterra, Spain.

出版信息

Gen Pharmacol. 1988;19(3):393-7. doi: 10.1016/0306-3623(88)90035-3.

DOI:10.1016/0306-3623(88)90035-3
PMID:2970987
Abstract
  1. Effects of two doses of cyproterone acetate (CA) and flutamide (FLU) (50 and 100 mg/kg/3 days) on the testicular steroidogenesis in male rats have been investigated, by measuring the content of cytochrome P-450, cytochrome b5 and cytochrome c reductase activity in the microsomal fraction. 2. CA provoked a significant decrease in cytochrome P-450 content while FLU induced an increase with the lowest dose but a significant decrease after administration of 100 mg/kg. 3. On the other hand, in all cases the cytochrome b5 and cytochrome c reductase activity remained unchanged. 4. The plasma levels of LH and testosterone were measured after CA and FLU injection (50 and 100 mg/kg/3 days). 5. CA administration provoked a reduction in blood levels of these hormones while FLU induced a significant increase in both. 6. These data suggested that CA and FLU modified the cytochrome P-450 in rat testes by an indirect mechanism, probably through the modification of LH plasma levels.
摘要

相似文献

1
Microsomal effects of cyproterone acetate and flutamide in rat testis.
Gen Pharmacol. 1988;19(3):393-7. doi: 10.1016/0306-3623(88)90035-3.
2
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J Steroid Biochem. 1987 Jul;28(1):43-7. doi: 10.1016/0022-4731(87)90122-1.
3
[Effects of cyproterone acetate and flutamide on blood calcium and bone structure].
Arch Esp Urol. 1986 Oct;39(8):534-8.
4
Effect of flutamide or cyproterone acetate on pituitary and testicular hormones in normal men.氟他胺或醋酸环丙孕酮对正常男性垂体和睾丸激素的影响。
J Clin Endocrinol Metab. 1984 Nov;59(5):963-9. doi: 10.1210/jcem-59-5-963.
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Sex-specific action of antiandrogens on androgen induced changes in hepatic microsomal 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity in the rat.
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Effects of cyproterone acetate and flutamide on the testis and epididymis of the Indian wall lizard, Hemidactylus flaviviridis (Ruppell).
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7
[The pharmacologic profile of flutamide].
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8
Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment.自发性高血压大鼠血压的性别差异：抗雄激素治疗的影响。
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Testicular phosphatase activity in rats treated with cyproterone acetate & flutamide.用醋酸环丙孕酮和氟他胺处理的大鼠的睾丸磷酸酶活性。
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10
Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate.氟他胺、醋酸环丙孕酮和醋酸甲地孕酮的抗雄激素/雄激素活性比较。
Mol Cell Endocrinol. 1985 Oct;42(3):283-8. doi: 10.1016/0303-7207(85)90059-0.

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Flutamide. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in advanced prostatic cancer.氟他胺。对其药效学和药代动力学特性以及在晚期前列腺癌中的治疗效果的初步综述。
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