Arend Michael, Westermann Bernhard, Risch Nikolaus
Fachbereich Chemie und Chemietechnik der Universität - GH, Warburger Strasse 100, D-33098 Paderborn (Germany), Fax: (+49) 5251-60-3245.
Angew Chem Int Ed Engl. 1998 May 4;37(8):1044-1070. doi: 10.1002/(SICI)1521-3773(19980504)37:8<1044::AID-ANIE1044>3.0.CO;2-E.
Important building blocks for the synthesis of drugs or natural products are found in Mannich bases and their derivatives. Modern variants of the Mannich reaction that expand the potential of the classical intermolecular reaction significantly and enable efficient control of the regioselectivity and stereoselectivity are therefore the topic of intensive research. Intramolecular reactions, in particular as part of domino reaction sequences, often afford astoundingly simple and elegant approaches to complex target compounds.
在曼尼希碱及其衍生物中发现了用于合成药物或天然产物的重要构件。曼尼希反应的现代变体极大地扩展了经典分子间反应的潜力，并能够有效控制区域选择性和立体选择性，因此是深入研究的主题。分子内反应，特别是作为多米诺反应序列的一部分，常常为复杂目标化合物提供惊人简单而优雅的方法。
