一种对映选择性催化剂的高通量筛选方法。
A Method for High-Throughput Screening of Enantioselective Catalysts.
作者信息
Reetz Manfred T, Becker Michael H, Klein Heinz-Werner, Stöckigt Detlef
机构信息
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr (Germany), Fax: (+49) 208-306-2985.
出版信息
Angew Chem Int Ed Engl. 1999 Jun 14;38(12):1758-1761. doi: 10.1002/(SICI)1521-3773(19990614)38:12<1758::AID-ANIE1758>3.0.CO;2-8.
About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled substrates. The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo-enantiomeric products 2 and 3.
每天大约可以分析1000个外消旋化合物或带有对映异位基团的前手性底物的催化或化学计量不对称反应。在这种高效方法中，对映选择性通过使用同位素标记底物的电喷雾电离质谱法来确定。图中展示了1水解生成假对映体产物2和3后所得混合物的质谱图。
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